{"created":"2023-07-27T06:51:10.325281+00:00","id":44471,"links":{},"metadata":{"_buckets":{"deposit":"f46a7123-fe0c-4e9b-a9b1-d64c93e2dc1a"},"_deposit":{"created_by":18,"id":"44471","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44471"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044471","sets":["2812:2813:2822"]},"author_link":["450","76148"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-07","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2010-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肺線維化におけるB細胞の役割は明らかではない。抗CD20抗体を事前に投与してB細胞を除去したマウスにブレオマイシンを投与したところ、コントロール抗体を投与したマウスに比べ肺線維化は増悪した。遺伝的にB細胞を欠損したマウスにブレオマイシンを投与したところ野生型マウスに比べ肺線維化は増悪したが、事前に野生型マウスの制御性B細胞を移入したところ肺線維化は野生型マウスと同程度まで軽減した。以上より、肺線維化の発症期においてB細胞は抑制的に働いていることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Pathogenesis of pulmonary fibrosis remains unclear. B cell depletion before the induction of lung fibrosis substantially exacerbated disease symptoms. Similarly, pulmonary fibrosis was also significantly worse in genetically B cell-deficient. MT mice when compared with wild type mice. The adoptive transfer of wild type regulatory B cells into. MT mice before disease initiation significantly reduced pulmonary pathology in. MT mice. By contrast, B cell depletion during the inflammatory phase of pathology dramatically suppressed disease symptoms. Thus, B cells have important regulatory and pathogenic roles during the development of lung fibrosis.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22791061, 研究期間(年度):2010-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「肺線維化における制御性B細胞の役割の検討」課題番号22791061\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22791061/22791061seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050813","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60420329"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60420329","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791061/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791061/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22791061/22791061seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22791061/22791061seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-21"}],"displaytype":"detail","filename":"ME-PR-HAMAGUCHI-Y-kaken 2012-4p.pdf","filesize":[{"value":"786.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HAMAGUCHI-Y-kaken 2012-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44471/files/ME-PR-HAMAGUCHI-Y-kaken 2012-4p.pdf"},"version_id":"c92beeb3-2c1d-4525-bbb9-56da98a4dc1f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肺線維化における制御性B細胞の役割の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肺線維化における制御性B細胞の役割の検討"},{"subitem_title":"The role of regulatory B cells in lung fibrosis model","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-21"},"publish_date":"2018-05-21","publish_status":"0","recid":"44471","relation_version_is_last":true,"title":["肺線維化における制御性B細胞の役割の検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:28:18.985265+00:00"}