{"created":"2023-07-27T06:51:10.369872+00:00","id":44472,"links":{},"metadata":{"_buckets":{"deposit":"e435b313-ef3c-4e71-a35e-d4dba11e2ede"},"_deposit":{"created_by":18,"id":"44472","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44472"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044472","sets":["2812:2813:2824"]},"author_link":["450","76148"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-04-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2008-2009","bibliographic_titles":[{"bibliographic_title":"平成21(2009)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2009 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CD20抗体を用いたB細胞除去療法が液性免疫に及ぼす影響については不明な点が多いため、マウスを用いた実験系で検討した。抗CD20抗体によるB細胞除去は抗体のクラススイッチを阻害し記憶B細胞を除去したが、血清中の免疫グロブリン値や抗原特異的抗体価、骨髄中の形質細胞数は変わらなかった。以上の結果から、CD20抗体療法は成熟B細胞や記憶B細胞を除去するものの既存の抗体価に影響を与えないことが明らかになった。","subitem_description_type":"Abstract"},{"subitem_description":"The full effects of B cell depletion on humoral immunity are largely unknown. To address this issue, mature B cells were depleted in mice using CD20 mAb. CD20^+ B cell depletion prevented humoral immune responses and class switching, and depleted B cell memory. Nonetheless, B cell depletion did not affect serum Ig levels, Ag-specific antibody titers, or bone marrow antibody-secreting plasma cell numbers. Thus, depleting mature and memory B cells does not have a dramatic negative effect on pre-existing antibody levels.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「CD20抗体によるB細胞除去療法が免疫応答に及ぼす影響についての検討」課題番号20790790\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790790/20790790seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050814","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60420329"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60420329","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790790/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790790/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790790/20790790seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790790/20790790seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-21"}],"displaytype":"detail","filename":"ME-PR-HAMAGUCHI-Y-kaken 2010-5p.pdf","filesize":[{"value":"445.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HAMAGUCHI-Y-kaken 2010-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44472/files/ME-PR-HAMAGUCHI-Y-kaken 2010-5p.pdf"},"version_id":"20bf85e4-bfe3-4ed9-915d-be07218441ce"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"CD20抗体によるB細胞除去療法が免疫応答に及ぼす影響についての検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CD20抗体によるB細胞除去療法が免疫応答に及ぼす影響についての検討"},{"subitem_title":"The effect of B cell depletion on humoral responses during anit-CD20 mAb immunotherapy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2824"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-21"},"publish_date":"2018-05-21","publish_status":"0","recid":"44472","relation_version_is_last":true,"title":["CD20抗体によるB細胞除去療法が免疫応答に及ぼす影響についての検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:15:18.730574+00:00"}