{"created":"2023-07-27T06:51:11.080373+00:00","id":44493,"links":{},"metadata":{"_buckets":{"deposit":"6f2fadd6-289d-4015-b861-f98e8d2b9023"},"_deposit":{"created_by":18,"id":"44493","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44493"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044493","sets":["2812:2813:2820"]},"author_link":["76362","76363"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"カルボン酸を有する薬は生体内でグルクロン酸抱合を受けることが多いが、この抱合体（アシルグルクロニド:AG）は肝障害をはじめとする様々な障害を引き起こすことが報告されている。本研究では、AGを加水分解する酵素としてα/β ヒドロラーゼドメインコンテイニング10 (ABHD10)を同定し、ミコフェノール酸、プロベネシドやジクロフェナクといった様々な薬物のAGを加水分解することを明らかにした。また、マウスを用いた検討より、ABHD10の機能が阻害されるとAGの血中濃度が上昇し、毒性発現の危険性が高まることを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"In general, drugs containing carboxylic acid are metabolized to acyl-glucuronide (AG) forms, which are considered to cause various toxicities including hepatotoxicity and anaphylaxis, in body. Therefore, it is conceivable that the enzymes hydrolyzing AG can attenuate the drug-induced toxicities. In this study, the enzyme responsible for AG hydrolysis was identified and its function was clarified. By the purification from human livers, alpha/beta hydrolase domain containing 10 (ABHD10) was identified as an AG hydrolase. ABHD10 could hydrolyze various kinds of AG such as AGs of mycophenolic acid, probenecid, and diclofenac. For in vivo study, mice pre-treated with an ABHD10 inhibitor showed the significantly higher AG plasma concentration compared with non-treated mice after an oral administration of diclofenac. Thus, it was clarified in vivo that ABHD10 can affect the plasma concentration of AGs. ABHD10 may play important roles for attenuation of the AGs-induced toxicity.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23590174, 研究期間(年度):2011-2013","subitem_description_type":"Other"},{"subitem_description":"出典：「アシルグルクロナイドを加水分解する新規薬物代謝酵素の同定および毒性学的意義」研究成果報告書　課題番号23590174\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590174/23590174seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050834","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域薬学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00532300"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00532300","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590174/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590174/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590174/23590174seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590174/23590174seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-31"}],"displaytype":"detail","filename":"PH-PR-FUKAMI-T-kaken 2014-4p.pdf","filesize":[{"value":"150.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-FUKAMI-T-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44493/files/PH-PR-FUKAMI-T-kaken 2014-4p.pdf"},"version_id":"dad8e99e-32ab-4d8d-a9e2-073e2601afe5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"アシルグルクロナイドを加水分解する新規薬物代謝酵素の同定および毒性学的意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アシルグルクロナイドを加水分解する新規薬物代謝酵素の同定および毒性学的意義"},{"subitem_title":"Toxicological significance of novel esterases involved in the hydrolysis of acyl-glucuronides","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-31"},"publish_date":"2018-05-31","publish_status":"0","recid":"44493","relation_version_is_last":true,"title":["アシルグルクロナイドを加水分解する新規薬物代謝酵素の同定および毒性学的意義"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:19:41.424291+00:00"}