{"created":"2023-07-27T06:51:11.124478+00:00","id":44494,"links":{},"metadata":{"_buckets":{"deposit":"5495c366-995c-4f7e-b561-8da6e81e5b75"},"_deposit":{"created_by":18,"id":"44494","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44494"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044494","sets":["2812:2813:2823"]},"author_link":["76362","76363"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-17","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2009-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヒトアリルアセタミドデアセチラーゼ(AADAC)が肝毒性や腎毒性が副作用として報告されている前立腺癌治療薬フルタミド、解熱鎮痛薬フェナセチン、抗結核薬リファマイシンの加水分解を触媒することを明らかにし、薬物代謝においてもAADACが重要であることを明らかにした。また、HNF4・、SHP、FXRなどの転写因子および核内受容体を介して胆汁酸によりAADAC発現量が低下することが明らかとなった。","subitem_description_type":"Abstract"},{"subitem_description":"This study demonstrated that human arylacetamide deacetylase (AADAC) catalyzes the hydrolysis of flutamide, phenacetin, and rifamycins, which are reported to be associated with toxicity. In addition, it was found that the expression level of AADAC mRNA was decreased by bile acid through the repression of HNF4a activity by FXR-induced SHP.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21790148, 研究期間(年度):2009-2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ヒトオーファンカルボキシルエステラーゼの薬物動態および毒性発現における関与」課題番号21790148\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790148/21790148seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050835","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00532300"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00532300","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790148/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790148/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790148/21790148seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790148/21790148seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-31"}],"displaytype":"detail","filename":"PH-PR-FUKAMI-T-kaken 2011-4p.pdf","filesize":[{"value":"185.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-FUKAMI-T-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44494/files/PH-PR-FUKAMI-T-kaken 2011-4p.pdf"},"version_id":"b1cc570c-a030-4df3-9c72-b3e06705c121"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒトオーファンカルボキシルエステラーゼの薬物動態および毒性発現における関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒトオーファンカルボキシルエステラーゼの薬物動態および毒性発現における関与"},{"subitem_title":"Involvement of human orphan carboxylesterase in drug metabolism and toxicitylesterase in drug metabolism and toxicity","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-31"},"publish_date":"2018-05-31","publish_status":"0","recid":"44494","relation_version_is_last":true,"title":["ヒトオーファンカルボキシルエステラーゼの薬物動態および毒性発現における関与"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:17:43.065105+00:00"}