{"created":"2023-07-27T06:51:11.301938+00:00","id":44498,"links":{},"metadata":{"_buckets":{"deposit":"cac24497-8d3b-42e1-8662-3d209c502cfd"},"_deposit":{"created_by":18,"id":"44498","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44498"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044498","sets":["2812:2813:2822"]},"author_link":["76366","2309"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヒト肝臓中に発現している転写因子HNF4αがmiR-24とmiR-34aによって、PPARαがmiR-21とmiR-27bによって、そしてARNTがmiR-24によって制御されていることを明らかにした。この発現制御機構は、それぞれの下流遺伝子の発現量にも影響を及ぼし、薬物代謝能だけでなく胆汁酸合成、脂質代謝、異物解毒能やストレス応答の個人差の原因となっていることを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"We found that the expression of HNF4α, PPARα, and ARNT in human liver is regulated by miRNAs. The miRNA? dependent regulation of these transcription factors affects the expression of their downstream genes, being a crucial factor of interindividual variability of drug metabolism, bile acid synthesis, lipid metabolism, detoxification of xenobiotics, and response to stimuli.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21390043, 研究期間(年度):2009-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ヒト肝薬物代謝能を制御するmicroRNA: 個人差解明のための革新的基盤研究」課題番号21390043\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390043/21390043seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050839","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学新学術創成研究機構ナノ生命科学研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70266162"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70266162","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390043/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390043/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390043/21390043seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390043/21390043seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-31"}],"displaytype":"detail","filename":"PH-PR-NAKAJIMA-M-kaken 2012-5p.pdf","filesize":[{"value":"430.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-NAKAJIMA-M-kaken 2012-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44498/files/PH-PR-NAKAJIMA-M-kaken 2012-5p.pdf"},"version_id":"40043604-c474-4dc2-951f-827ba85b5c8c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒト肝薬物代謝能を制御するmicroRNA: 個人差解明のための革新的基盤研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト肝薬物代謝能を制御するmicroRNA: 個人差解明のための革新的基盤研究"},{"subitem_title":"microRNA regulation human drug metabolism: innovative study for the interindividual variability","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-31"},"publish_date":"2018-05-31","publish_status":"0","recid":"44498","relation_version_is_last":true,"title":["ヒト肝薬物代謝能を制御するmicroRNA: 個人差解明のための革新的基盤研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:28:17.632915+00:00"}