{"created":"2023-07-27T06:51:12.014083+00:00","id":44527,"links":{},"metadata":{"_buckets":{"deposit":"d49c6f7f-ac92-4076-bb66-933c06d5c4cd"},"_deposit":{"created_by":18,"id":"44527","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44527"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044527","sets":["2812:2813:2818"]},"author_link":["76422","76421"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2013-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"従来の不斉触媒を用いた不斉アミド化反応では、カルボン酸とアミンから光学活性アミドを合成する際、ラセミ体アミンを速度論的光学分割する例しかなかった。本研究では、トリアジンを基盤とした脱水縮合反応を用い、触媒がラセミ体カルボン酸の不斉を制御する反応の開発に取り組んだ。その結果、用いるキラル第三級アミンやクロロトリアジンの構造を調整する事で、これまでにない初の反応様式で光学活性アミドが得られることを明らかとした。また、上記トリアジンの研究で得られた知見を利用して、新しいベンジル化剤の開発、トリアジニルアンモニウムの効果的な脱離反応などの解明に至った。","subitem_description_type":"Abstract"},{"subitem_description":"There were only a few examples of kinetic resolution of racemic amines by chiral catalysts when optically active amides are prepared from carboxylic acids and amines. In contrast, a chiral catalyst developed in this study recognized stereogenic centers of carboxylic acids in a triazine-based dehydrocondensing reaction. It was elucidated that structures of chiral tertiary amines and chlorotriazines affected enantio-selectivity of the products. This is a first catalytic reaction system that would afford chiral amides from racemic carboxylic acids, and therefore, it would be useful for development of pharmaceutical drugs. In addition, by using knowledge obtained in this study, novel triazine-based benzylating reagents and effective elimination reactions of triazinylammonium salts were developed.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25460013, 研究期間(年度):2013-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「プロトン性溶媒中における触媒的斉アミド化反応の開発とD-アミノ酸の選択的標識化」課題番号25460013\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25460013/25460013seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050868","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80453835"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80453835","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460013/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460013/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25460013/25460013seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25460013/25460013seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-31"}],"displaytype":"detail","filename":"PH-PR-KUNISHIMA-M-kaken 2016c-4p.pdf","filesize":[{"value":"86.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-KUNISHIMA-M-kaken 2016c-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44527/files/PH-PR-KUNISHIMA-M-kaken 2016c-4p.pdf"},"version_id":"f0931868-9e65-4d92-ad97-3e2302724335"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"プロトン性溶媒中における触媒的斉アミド化反応の開発とD-アミノ酸の選択的標識化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"プロトン性溶媒中における触媒的斉アミド化反応の開発とD-アミノ酸の選択的標識化"},{"subitem_title":"Development of catalytic and asymmetric amide-forming reactions in protic solvents and stereo-selective labeling of D-amino acids","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-31"},"publish_date":"2018-05-31","publish_status":"0","recid":"44527","relation_version_is_last":true,"title":["プロトン性溶媒中における触媒的斉アミド化反応の開発とD-アミノ酸の選択的標識化"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:56:40.968678+00:00"}