{"created":"2023-07-27T06:51:12.281358+00:00","id":44533,"links":{},"metadata":{"_buckets":{"deposit":"0ec390ed-b555-4d90-8176-d5e58a92783b"},"_deposit":{"created_by":18,"id":"44533","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44533"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044533","sets":["2812:2813:2822"]},"author_link":["76429","76454"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 若手研究(A) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"3-エトキシシクロブタノン誘導体を適切なルイス酸を用いて活性化して1, 4-双極性活性種を生成させ、アリルシラン、シリルエノールエーテル、イミン、およびインドール類と反応させたところ、目的とする形式的[ 4+2]環化付加反応が円滑に進行し、対応する六員環化合物が効率的に得られることを明らかにした。さらにこの反応を用いて、生理活性物質であるブレマゾシンおよびアスピドスペルジミンの全合成を達成した。","subitem_description_type":"Abstract"},{"subitem_description":"We found that formal[ 4+2] cycloaddition reactions of 3-ethoxycyclobutanones with allylsilanes, silyl enol ethers, imines, or indoles proceeded smoothly to afford the corresponding six-membered cyclic compounds in high yields by activating the cyclobutanones with appropriate Lewis acids. We accomplished total synthesis of(±)-bremazocine and(±)-aspidospermidine by using the new cycloaddition.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21689001, 研究期間(年度):2009-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「1, 4-双極性活性種を用いる新しい環化付加反応の開発と生理活性物質合成への応用」課題番号21689001\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21689001/21689001seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050874","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域薬学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50328580"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50328580","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21689001/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21689001/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21689001/21689001seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21689001/21689001seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-31"}],"displaytype":"detail","filename":"PH-PR-MATSUO-J-kaken 2012-6p.pdf","filesize":[{"value":"327.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-MATSUO-J-kaken 2012-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44533/files/PH-PR-MATSUO-J-kaken 2012-6p.pdf"},"version_id":"c41987cb-7ba6-4ab4-bb94-f9d9eb2c8b1f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"1, 4-双極性活性種を用いる新しい環化付加反応の開発と生理活性物質合成への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"1, 4-双極性活性種を用いる新しい環化付加反応の開発と生理活性物質合成への応用"},{"subitem_title":"Development of new cycloaddition reactions with 1,4-Zwitterionic intermediates and application to synthesis of bioactive compounds","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-31"},"publish_date":"2018-05-31","publish_status":"0","recid":"44533","relation_version_is_last":true,"title":["1, 4-双極性活性種を用いる新しい環化付加反応の開発と生理活性物質合成への応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:28:16.135813+00:00"}