{"created":"2023-07-27T06:51:12.692152+00:00","id":44542,"links":{},"metadata":{"_buckets":{"deposit":"b084467c-be64-45a0-8786-1ea662ec3d24"},"_deposit":{"created_by":18,"id":"44542","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44542"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044542","sets":["2812:2813:2817"]},"author_link":["16426","246"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-09-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2015-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究成果により、炎症を媒介するケミカルメディエータであるprostaglandin(PG) E2は、炎症組織で活性化されるマクロファージ細胞(Mφ)内に発現するPGトランスポーター(OATP2A1)により、リソゾーム等の酸性オルガネラに貯留された後、炎症刺激に伴って開口分泌されることが示された。げっ歯類動物を用いたOATP2A1の遺伝的および化学的抑制は内毒素による発熱効果を減弱させたことから、OATP2A1は解熱薬の新規標的として期待される。","subitem_description_type":"Abstract"},{"subitem_description":"The present study indicates that an important chemical mediator prostaglandin (PG) E2 is transported into acidic organelles including lysosome via OATP2A1, which is a transporter with high affinity to PGE2, in macrophages activated under inflammatory condition, and then it is secreted by exocytosis. Since genetic and chemical suppression of Oatp2a1 attenuated endotoxin-induced fever in rodent models, OATP2A1 is expected to be a novel target for antipyretic drugs.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K15181, 研究期間(年度):2015-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「プロスタグランジン輸送体を作用標的とする新規抗炎症薬の提唱」研究成果報告書　課題番号15K15181\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15181/15K15181seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050883","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30541742"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30541742","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15181/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15181/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15181/15K15181seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15181/15K15181seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-31"}],"displaytype":"detail","filename":"PH-PR-NAKANISHI-T-kaken 2017-5p.pdf","filesize":[{"value":"353.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-NAKANISHI-T-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44542/files/PH-PR-NAKANISHI-T-kaken 2017-5p.pdf"},"version_id":"e6b38532-4a2e-4c8a-b595-d6116478f875"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"プロスタグランジン輸送体を作用標的とする新規抗炎症薬の提唱","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"プロスタグランジン輸送体を作用標的とする新規抗炎症薬の提唱"},{"subitem_title":"Study on prostaglandin transporter as a novel target for anti-inflammatory drugs","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-31"},"publish_date":"2018-05-31","publish_status":"0","recid":"44542","relation_version_is_last":true,"title":["プロスタグランジン輸送体を作用標的とする新規抗炎症薬の提唱"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:36:05.626570+00:00"}