{"created":"2023-07-27T06:51:12.783063+00:00","id":44544,"links":{},"metadata":{"_buckets":{"deposit":"e010c410-c6ff-4338-bbec-9cc464552be8"},"_deposit":{"created_by":18,"id":"44544","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44544"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044544","sets":["2812:2813:2823"]},"author_link":["16426","246"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2009-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 研究活動スタート支援 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"5-アミノレブリン酸(5-ALA)は腫瘍組織選択的に光増感性蛍光物質プロトポルフィリンIX(PPIX)の蓄積を誘導する光力学療法薬である。しかし、5-ALAによる腫瘍組織選択的PPIX誘導メカニズムは未解明である。本研究では、光線力学治療・診断に有効な腫瘍種を判断する分子診断技術の確立を目指し、5-ALAに曝露したヒト腫瘍組織由来株化がん細胞において、細胞内PPIX蓄積性決定因子を検討した。その結果、細胞内PPIX蓄積は、PPIX生合成、フェロキラターゼ酵素活性、およびPPIXの排出により決定されることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"5-Aminolevulinic acid is one of the most potent photodynamic therapeutic agents, because it induces tumor cell-specific intracellular accumulation of a photosensitizer, protoporphyrin IX (PPIX). However, molecular mechanisms of such 5-ALA-induced PPIX accumulation remain unclear. In the current study, in order to establish a basis to predict efficacy of photodynamic therapy to treat cancer, molecular mechanisms of intracellular accumulation of PPIX induced by 5-ALA were studied in various human cancer cell lines exposed to 5-ALA. Results suggested that PPIX accumulation is likely determined by PPIX biosynthesis, ferrochelatase (FECH) activity and PPIX efflux.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「腫瘍組織選択的5-アミノレブリン酸誘導プロトポルフィリン蓄積メカニズムの解明」課題番号21890084\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21890084/21890084seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050885","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30541742"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30541742","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21890084/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21890084/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21890084/21890084seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21890084/21890084seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-31"}],"displaytype":"detail","filename":"PH-PR-NAKANISHI-T-kaken 2011-4p.pdf","filesize":[{"value":"212.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-NAKANISHI-T-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44544/files/PH-PR-NAKANISHI-T-kaken 2011-4p.pdf"},"version_id":"da8386bb-682d-46b2-8488-192e4187802d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"腫瘍組織選択的5-アミノレブリン酸誘導プロトポルフィリン蓄積メカニズムの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腫瘍組織選択的5-アミノレブリン酸誘導プロトポルフィリン蓄積メカニズムの解明"},{"subitem_title":"Evaluation of molecular mechanisms of tumor-specific protoporphyrin accumulation induced by 5-aminolevulinic acid","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-31"},"publish_date":"2018-05-31","publish_status":"0","recid":"44544","relation_version_is_last":true,"title":["腫瘍組織選択的5-アミノレブリン酸誘導プロトポルフィリン蓄積メカニズムの解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:17:37.452697+00:00"}