{"created":"2023-07-27T06:51:14.195518+00:00","id":44577,"links":{},"metadata":{"_buckets":{"deposit":"8b76b9a4-a996-4e3f-b645-2c6a69f109e3"},"_deposit":{"created_by":18,"id":"44577","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44577"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044577","sets":["2812:2813:2822"]},"author_link":["69343","34"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"尿酸調節に働く腎臓の新規トランスポ-タ-ならびに薬物との相互作用を明確にするとともに、解析モデルとしてラットの有用性をラット尿酸トランスポーターの詳細を解析することにより明らかにした。さらにヒトへの展開を目的としたPETプローブの合成ならびに腎外排泄経路として消化管の重要性を分子論・速度論的に明確にした。本成果は今後の尿酸変動機構の解析並びに高尿酸血症との治療薬の探索・評価に有用である。","subitem_description_type":"Abstract"},{"subitem_description":"Transporter molecule that control renal handling of uric acid and effect of uricosuric-and anti-uricosuric drugs were analyzed using in vitro and in vivo model. OAT2 was newly found as the uric acid transporter in kidney. As the animal model, uric transporters expressed in rats were characterized and found to be useful as the model of uric acid disposition. In addition, as the extra-renal elimination pathways of uric acid, intestinal secretion was found to be very important and the BCRP transporter was found to be responsible for that process. Furthermore, for in vivo analysis in human, the method for the synthesis of PET probe of uric acid was succeeded. It was preliminarily applied in PET analysis in rats. All these studies related to the mechanism and evaluation method of uric acid disposition is useful for future development of drugs that can control serum uric acid level and physiological and pathological significance of uric acid.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21390044, 研究期間(年度):2009-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「尿酸動態調節機構の解明に基づく血清尿酸値変動評価システムの樹立」課題番号21390044\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390044/21390044seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050918","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域薬学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20155237"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20155237","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390044/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390044/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390044/21390044seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390044/21390044seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-01"}],"displaytype":"detail","filename":"PH-PR-TAMAI-I-kanen 2012-6p.pdf","filesize":[{"value":"330.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-TAMAI-I-kanen 2012-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44577/files/PH-PR-TAMAI-I-kanen 2012-6p.pdf"},"version_id":"045df7ae-56ba-4082-b317-a8ccf3f9035e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"尿酸動態調節機構の解明に基づく血清尿酸値変動評価システムの樹立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"尿酸動態調節機構の解明に基づく血清尿酸値変動評価システムの樹立"},{"subitem_title":"Clarification and evaluation of regulation mechanism of uric acid","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-01"},"publish_date":"2018-06-01","publish_status":"0","recid":"44577","relation_version_is_last":true,"title":["尿酸動態調節機構の解明に基づく血清尿酸値変動評価システムの樹立"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:28:14.018678+00:00"}