{"created":"2023-07-27T06:51:14.518103+00:00","id":44590,"links":{},"metadata":{"_buckets":{"deposit":"b2334e24-aeaf-4d70-ac56-d92b0d138afa"},"_deposit":{"created_by":18,"id":"44590","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44590"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044590","sets":["2812:2813:2817"]},"author_link":["640","76675"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2012-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"抗真菌薬ボリコナゾールが小児で成人より高い投与量が必要な理由についてラットを用いて調べた．その結果，薬物代謝酵素のフラビン含有モノオキシゲナーゼ（FMO）活性が幼若期で高いことが理由であることを明らかにした．一方，胆汁中に排泄された薬を再利用する働き（腸肝循環）の寄与は成長に伴って発達するため，腸肝循環を受ける薬物間の相互作用は成熟ラットで強く現れることがわかった．\n以上，成長に伴うFMO活性や腸肝循環の変動が薬物体内動態や薬物間相互作用を変動させる知見を得た.","subitem_description_type":"Abstract"},{"subitem_description":"In vivo kinetics of voriconazole was found to depend on the age in human and rats. From this research with rats, the high activity of flavin-containing monooxygenase at immature stages contributed to this age-related alteration of voriconazole pharmacokinetics. On the other hand, because the capacity of enterohepatic circulation progress with growth, the drug-drug interaction related to enterohepatic circulation at mature stages is more strongly than at immature stages.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24590184, 研究期間(年度):2012-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「成長過程や身体機能の変化に伴う薬物体内動態変動要因の検索」研究成果報告書　課題番号24590184\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24590184/24590184seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050931","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60401890"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60401890","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590184/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590184/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24590184/24590184seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24590184/24590184seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-04"}],"displaytype":"detail","filename":"PH-PR-ISHIZAKI-J-kaken 2017-5p.pdf","filesize":[{"value":"585.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-ISHIZAKI-J-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44590/files/PH-PR-ISHIZAKI-J-kaken 2017-5p.pdf"},"version_id":"36517af0-2996-4924-b125-45040efcb145"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"成長過程や身体機能の変化に伴う薬物体内動態変動要因の検索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"成長過程や身体機能の変化に伴う薬物体内動態変動要因の検索"},{"subitem_title":"Research of Change in Pharmacokinetics Related with Age and/or Physical Function","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-04"},"publish_date":"2018-06-04","publish_status":"0","recid":"44590","relation_version_is_last":true,"title":["成長過程や身体機能の変化に伴う薬物体内動態変動要因の検索"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:36:02.464309+00:00"}