{"created":"2023-07-27T06:51:14.564568+00:00","id":44591,"links":{},"metadata":{"_buckets":{"deposit":"243168ba-7627-4afb-8ef7-1b96cde5ce32"},"_deposit":{"created_by":18,"id":"44591","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44591"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044591","sets":["2812:2813:2822"]},"author_link":["640","76675"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ボリコナゾール,ミコフェノール酸,バルプロ酸について,臨床使用実態下での成長過程における動態変動を検証し,その要因を検討した.その結果,いずれの薬物でも小児では成人より高い投与量が必要なこと,動物実験より成長過程での薬物代謝酵素活性の変動や,成長に伴う腸肝循環能の発達の差により体内動態が変動することを解明した.さらに,トランスポーターの発現も成長に伴い変動しており動態変動への関与を示唆する知見を得た.","subitem_description_type":"Abstract"},{"subitem_description":"The changes in pharmacokinetics with aging of voriconazole, mycophenolic acid and valproate were investigated in human and rats. In all three drugs, pediatric patients were required a higher dose than adults to achive a similar the trough plasma concentration. I show that these differences are due to the activity of drug metabolism and the capacity of enterohepatic circulation, and suggest that changes of drug transpoter(s) expression over the course of development affect the disposition kinetics.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21590154, 研究期間(年度):2009-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「小児薬物療法適正化を目的とした成長過程における薬物体内動態変動要因の検索」課題番号21590154\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590154/21590154seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050932","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域薬学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60401890"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60401890","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590154/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590154/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590154/21590154seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590154/21590154seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-04"}],"displaytype":"detail","filename":"PH-PR-ISHIZAKI-J-kaken 2012-4p.pdf","filesize":[{"value":"324.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-ISHIZAKI-J-kaken 2012-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44591/files/PH-PR-ISHIZAKI-J-kaken 2012-4p.pdf"},"version_id":"98868418-7b07-461a-9b5e-f0d154d24317"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"小児薬物療法適正化を目的とした成長過程における薬物体内動態変動要因の検索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"小児薬物療法適正化を目的とした成長過程における薬物体内動態変動要因の検索"},{"subitem_title":"Research of Change in Pharmacokinetics as a Function of Age Intended Optimization of Drug Therapy in children","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-04"},"publish_date":"2018-06-04","publish_status":"0","recid":"44591","relation_version_is_last":true,"title":["小児薬物療法適正化を目的とした成長過程における薬物体内動態変動要因の検索"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:28:11.122438+00:00"}