{"created":"2023-07-27T06:51:14.610039+00:00","id":44592,"links":{},"metadata":{"_buckets":{"deposit":"5864eb6f-3464-498c-b1fe-240fd00edaa8"},"_deposit":{"created_by":18,"id":"44592","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44592"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044592","sets":["2812:2813:2818"]},"author_link":["76678","76677"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2013-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ゲムシタビン塩酸塩（GEM）やオキサリプラチン（L-OHP）を末梢静脈から投与した際に生じる血管痛は，がん薬物療法を行う上での大きな問題点となっている．血管痛を予防・軽減をするためには，血管痛の発現機序を明らかにしたうえで，予防対策を考案する必要がある．そこで，本申請課題では，基礎研究・臨床研究を統合し，発痛機序および予防対策について検討した．その結果，血管痛は投与する抗がん剤の投与量に依存することから，単位時間当たりの投与量を少なくする（投与時間を延長する）ことで予防できることが示唆された．また，血管痛を起こす薬剤により，発痛機序が異なる可能性が示された．","subitem_description_type":"Abstract"},{"subitem_description":"Vascular pain induced by administration of gemcitabine (GEM) or oxaliplatin (L-OHP) via peripheral venous is major problem in patients received cancer chemotherapy. To elucidate the mechanism of vascular pain will be required before prophylactic methods are established in clinical setting. The purpose of this study was to develop a useful prophylactic method for vascular pain in clinical setting and to clarify the inciting factor of pain that occur around the injection site or peripheral vein by using approach both basic and clinical studies. The results in this study suggested that vascular pain is depend on the dosage per unit of time, resulting from that extending the administration time of GEM or L-OHP could reduce the intensity of vascular pain and the mechanism of vascular pain could differ from agents associated with this pain.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25860109, 研究期間(年度):2013-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「抗癌剤による血管痛の誘発要因および予防策の基礎・臨床統合的検証」課題番号25860109\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25860109/25860109seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050933","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00467101"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00467101","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860109/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860109/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25860109/25860109seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25860109/25860109seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-04"}],"displaytype":"detail","filename":"PH-PR-SUGA-Y-kaken 2016-4p.pdf","filesize":[{"value":"237.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-SUGA-Y-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44592/files/PH-PR-SUGA-Y-kaken 2016-4p.pdf"},"version_id":"351a16be-04c9-4798-aacb-ba4932c239b6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"抗癌剤による血管痛の誘発要因および予防策の基礎・臨床統合的検証","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗癌剤による血管痛の誘発要因および予防策の基礎・臨床統合的検証"},{"subitem_title":"Development of prophylactic method and clarification of mechanism for anti-tumor drug-induced vascular pain by using approach both basic and clinical syudies","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-04"},"publish_date":"2018-06-04","publish_status":"0","recid":"44592","relation_version_is_last":true,"title":["抗癌剤による血管痛の誘発要因および予防策の基礎・臨床統合的検証"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:55:59.355938+00:00"}