{"created":"2023-07-27T06:51:14.745549+00:00","id":44595,"links":{},"metadata":{"_buckets":{"deposit":"89f6cc50-301f-4246-a595-5733b3ced870"},"_deposit":{"created_by":18,"id":"44595","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44595"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044595","sets":["2812:2813:2819"]},"author_link":["76680","76681"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2013-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"NF-κB経路は抗菌ペプチドやサイトカインの産生を制御するシグナル伝達経路として、自然免疫における中心的な役割を担っている。これまでに、生物に普遍的な自然免疫制御機構の新たな一面を明らかにするため、ショウジョウバエ幼虫における過剰発現スクリーニングを行い、抗菌ペプチドDiptericinの発現を誘導する新規遺伝子であるCG8863を同定している。そこで本研究では、CG8863ノックダウン個体を用いた細菌感染実験により、CG8863のNF-κB経路への関与を示した。さらにCG8863のほ乳類ホモログがIκBαのリン酸化を制御することでNF-κB経路の活性化に寄与している可能性を示唆した。","subitem_description_type":"Abstract"},{"subitem_description":"The NF-κB pathway is a phylogenetically conserved signaling pathway that has a central role for inflammatory and immune responses. Ｗe demonstrated that a co-chaperone protein CG8863 is involved in the activation of the canonical NF-κB signaling in flies and in human cultured cells. Overexpression of CG8863 induced an antimicrobial pepide expression in Drosophila. Conversely, knockdown of CG8863 resulted in the reduced expression of antimicrobial peptides and higher susceptibility to Gram-negative bacterial infection in flies. Similarly, Toll-like receptor-stimulated IκB phosphorylation and NF-κB activation was supressed by the knockdown of human CG8863 in HEK293 cells. IKK-overexpession induced NF-κB phosphorylation was also compromised in the CG8863-knockdown cells. Our study reveals a novel conserved regulator of the NF-κB pathway acting at the level of IκB phosphorylation.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25860038, 研究期間(年度):2013-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「NF-κBの活性化に必須な新規遺伝子mCG8863の機能解析」課題番号25860038\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25860038/25860038seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050936","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90613167"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90613167","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860038/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860038/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25860038/25860038seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25860038/25860038seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-04"}],"displaytype":"detail","filename":"PH-PR-KURAISHI-T-kaken 2015-5p.pdf","filesize":[{"value":"92.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-KURAISHI-T-kaken 2015-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44595/files/PH-PR-KURAISHI-T-kaken 2015-5p.pdf"},"version_id":"49f5eee9-b0d4-428d-b3df-e084ae10495c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"NF-κBの活性化に必須な新規遺伝子mCG8863の機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"NF-κBの活性化に必須な新規遺伝子mCG8863の機能解析"},{"subitem_title":"Role of mCG8863 for the activation of NF-κB","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-04"},"publish_date":"2018-06-04","publish_status":"0","recid":"44595","relation_version_is_last":true,"title":["NF-κBの活性化に必須な新規遺伝子mCG8863の機能解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:43:36.929110+00:00"}