{"created":"2023-07-27T06:51:14.790308+00:00","id":44596,"links":{},"metadata":{"_buckets":{"deposit":"5ab7c4cb-9817-49ac-ac77-477569c5cd28"},"_deposit":{"created_by":18,"id":"44596","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44596"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044596","sets":["2812:2813:2821"]},"author_link":["76680","76681"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2011-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 研究活動スタート支援 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"私たちは受容体型グアニル酸シクラーゼGyc76Cが自然免疫を調節する新規受容体であることを明らかにしてきた。\n本研究では、Gyc76Cのリガンドを同定することを目標として研究を進めた。ショウジョウバエ幼虫抽出液中に抗菌ペプチド発現を誘導する活性を見いだし、単離・精製し、新規自然免疫活性化因子を同定した。今後は、この因子がGyc76Cのリガンドであるか詳細な解析を進める。","subitem_description_type":"Abstract"},{"subitem_description":"We have revealed that Gyc76C, a receptor-type guanylate cyclase, mediates innate immunity. In this study, we sought to identify a ligand for Gyc76C.\nWe found that Drosophila larval extract has an activity that induces the expression of antimicrobial peptides in Drosophila cell line. The activity was purified to homogeneity and the amino acid sequence was determined, resulting in theidentification of a new protein that activates innate immune system in Drosophila. Further analysis should be done to validate that whether the identified protein would be a ligand for Gyc76C.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23890014, 研究期間(年度):2011-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「自然免疫を調節する受容体型グアニル酸シクラーゼGyc76Cのリガンド探索」課題番号23890014\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23890014/23890014seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050937","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域薬学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90613167"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90613167","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23890014/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23890014/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23890014/23890014seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23890014/23890014seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-04"}],"displaytype":"detail","filename":"PH-PR-KURAISHI-T-kaken 2013-5p.pdf","filesize":[{"value":"517.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-KURAISHI-T-kaken 2013-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44596/files/PH-PR-KURAISHI-T-kaken 2013-5p.pdf"},"version_id":"86e1fc96-18f3-403a-833e-bea29f96a081"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"自然免疫を調節する受容体型グアニル酸シクラーゼGyc76Cのリガンド探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"自然免疫を調節する受容体型グアニル酸シクラーゼGyc76Cのリガンド探索"},{"subitem_title":"Searching for a ligand that activates Gyc76C, a receptor-type guanylate cyclase which mediates innate immunity","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-04"},"publish_date":"2018-06-04","publish_status":"0","recid":"44596","relation_version_is_last":true,"title":["自然免疫を調節する受容体型グアニル酸シクラーゼGyc76Cのリガンド探索"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:41:24.340636+00:00"}