{"created":"2023-07-27T06:51:15.242878+00:00","id":44606,"links":{},"metadata":{"_buckets":{"deposit":"2a1adf99-57b7-462c-9535-a1c63c239b03"},"_deposit":{"created_by":18,"id":"44606","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44606"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044606","sets":["2812:2813:2817"]},"author_link":["76695","284"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肺癌における増殖因子受容体cMetと核内DNA複製酵素のTopoIの関連を検討した。１０種類の培養細胞を用いてcMetを検討したところ５細胞株でcMet高発現、リン酸化亢進を認めた。核内のTopoI発現、活性はcMet高発現細胞で高く活性も亢進しており、TopoI阻害剤の感受性と関連していた。cMet阻害で、 TopoIも低下した。下流シグランルの検討では、TopoI発現に関連する２９の候補遺伝子を同定した。臨床検体を用いた解析で、cMetは37.7%、TopoIは51.3％で陽性を指名し、有意な相関を認めた。cMetがTopoI発現を調節している可能性が示唆され、治療戦略確立が期待される。","subitem_description_type":"Abstract"},{"subitem_description":"We examined the relationship between cMet and Topoisomerase I lung cancer. Protein expression and phosphorylation of cMet using 10 lung cancer cell lines revealed high expression and hyperphosphorylation in 5 cell line.Expression and activity of Topo I were higher in cMet overexpressing cells and were related to the sensitivity of Topo I inhibitors. Inhibition of cMet by Met inhibitor also decreased Topo I. Upon examination of the downstream signaling, 29 candidate genes associated with Topo I expression were identified by cMet stimulation and suppression. In analysis using clinical donation, cMet nominated positive with 37.7% and TopoI at 51.3%, showing a significant correlation. This study suggests that cMet may regulate the expression of Topo I and we believe that it will bring important findings to establish future treatment strategies.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26430159, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「肺癌におけるcMetによるtopoisomeraseIの活性制御の解析」研究成果報告書　課題番号26430159\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26430159/26430159seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050947","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30272967"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30272967","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26430159/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26430159/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26430159/26430159seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26430159/26430159seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-04"}],"displaytype":"detail","filename":"ME-PR-KASAHARA-K-kaken 2017-5p.pdf","filesize":[{"value":"764.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KASAHARA-K-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44606/files/ME-PR-KASAHARA-K-kaken 2017-5p.pdf"},"version_id":"c205de32-4855-4f22-87ca-8d33ff2fb5ec"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肺癌におけるcMetによるtopoisomeraseIの活性制御の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肺癌におけるcMetによるtopoisomeraseIの活性制御の解析"},{"subitem_title":"Regulation of Topisomerase I activity by cMet in lung cancer","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-04"},"publish_date":"2018-06-04","publish_status":"0","recid":"44606","relation_version_is_last":true,"title":["肺癌におけるcMetによるtopoisomeraseIの活性制御の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:34:28.583979+00:00"}