{"created":"2023-07-27T06:51:16.554357+00:00","id":44635,"links":{},"metadata":{"_buckets":{"deposit":"a3de5dc0-551c-44c5-9847-62041125c6cb"},"_deposit":{"created_by":18,"id":"44635","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44635"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044635","sets":["2812:2813:2824"]},"author_link":["76746","374"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-05-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2008-2009","bibliographic_titles":[{"bibliographic_title":"平成21(2009)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2009 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"癌の分子レベルでの予防をめざして、癌で高発現しているTGF-β1 結合蛋白質 LTBP-1L (Latent TGF-β1 binding protein-1L)の働きと分子マーカーとしての有用性を検討した。培養細胞株での機能解析と、臨床症例での蛋白発現と臨床データの関連解析の結果、LTBP-1L 蛋白は細胞増殖能の活性化を通じて、癌の発生や進行に寄与する可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Latent transforming growth factor (TGF)-β binding protein-1 (LTBP-1) play important roles in the secretion and activation of TGF-β. In this study, to clarify the role of LTBP-1L protein in carcinoma cell, we performed in vitro functional analysis and clinical data analysis. Our results indicate that the LTBP-1L protein can contribute to tumor initiation and progression through the induction of cell growth activity. And we indicated the possibility of the LTBP-1L protein as cancer molecular marker.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「癌細胞におけるLTBP-1L蛋白の機能解明と癌分子マーカーとしての応用」課題番号20790421\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790421/20790421seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050976","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20293342"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20293342","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790421/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790421/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790421/20790421seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790421/20790421seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-07"}],"displaytype":"detail","filename":"ME-PR-HIGASHI-T-kaken 2010-4p.pdf","filesize":[{"value":"191.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HIGASHI-T-kaken 2010-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44635/files/ME-PR-HIGASHI-T-kaken 2010-4p.pdf"},"version_id":"19ede730-21c4-441a-ab70-69feb15dc26e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"癌細胞におけるLTBP-1L蛋白の機能解明と癌分子マーカーとしての応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"癌細胞におけるLTBP-1L蛋白の機能解明と癌分子マーカーとしての応用"},{"subitem_title":"Analysis of LTBP-1L protein in carcinoma cell and application as cancer molecular marker","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2824"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-07"},"publish_date":"2018-06-07","publish_status":"0","recid":"44635","relation_version_is_last":true,"title":["癌細胞におけるLTBP-1L蛋白の機能解明と癌分子マーカーとしての応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:15:13.103206+00:00"}