{"created":"2023-07-27T06:51:16.863229+00:00","id":44642,"links":{},"metadata":{"_buckets":{"deposit":"f156cea2-15dc-4d9e-869c-f39dbd587159"},"_deposit":{"created_by":18,"id":"44642","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44642"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044642","sets":["2812:2813:2816"]},"author_link":["76756","2860"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-17","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"錐体視細胞のオプシンを人為的に神経細胞に発現させると、光照射により神経細胞の電気活動と伝達物質の放出を抑制させることができる。本研究では、この手法を用い睡眠・覚醒制御システムの中核を担う視床下部神経系とモノアミン作動性神経系の機能的役割について解析を行った。\nまず、ナルコレプシー睡眠障害モデルマウスにおいて、扁桃体におけるセロトニン放出の低下が情動性脱力発作の発症をもたらしていることが明らかになった。また、覚醒制御に関わる視床下部外側野オレキシン神経が、青斑核ノルアドレナリン神経の活性化を介して、扁桃体で処理される恐怖記憶によって表出する恐怖反応の発現を促していることが明らかになった。","subitem_description_type":"Abstract"},{"subitem_description":"When cone opsins of photoreceptors are artificially expressed in neurons, light irradiation can suppress the neuronal activity and the release of transmitters from the neurons. Applying this method, we analyzed the functional roles of the hypothalamus and the monoaminergic system, which are the core of the sleep-wake regulatory system.\nFirst, reduction of serotonin release in the amygdala has been shown to result in the development of the cataplexy-like episode in the mice model of sleep disorder, narcolepsy. Second, in the fear conditioning test of mice the lateral hypothalamic orexin neurons involved in brain arousal have been elucidated to promote the fear-related behaviors regulated in the amygdala via the activation of noradrenergic neurons.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K01832, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「錐体オプシンを用いた光遺伝学的手法による睡眠・覚醒制御システム作動機序の解析」課題番号15K01832\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K01832/15K01832seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050983","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70399319"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70399319","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K01832/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K01832/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K01832/15K01832seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K01832/15K01832seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-15"}],"displaytype":"detail","filename":"ME-PR-MAEJIMA-T-kaken 2018-4p.pdf","filesize":[{"value":"216.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MAEJIMA-T-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44642/files/ME-PR-MAEJIMA-T-kaken 2018-4p.pdf"},"version_id":"b9f45735-ffc0-4242-857c-5bd453313165"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"錐体オプシンを用いた光遺伝学的手法による睡眠・覚醒制御システム作動機序の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"錐体オプシンを用いた光遺伝学的手法による睡眠・覚醒制御システム作動機序の解析"},{"subitem_title":"Analysis of sleep-wake regulatory system by optogenetics featuring cone opsins","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-15"},"publish_date":"2019-04-15","publish_status":"0","recid":"44642","relation_version_is_last":true,"title":["錐体オプシンを用いた光遺伝学的手法による睡眠・覚醒制御システム作動機序の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:01:09.294246+00:00"}