{"created":"2023-07-27T06:51:16.956057+00:00","id":44645,"links":{},"metadata":{"_buckets":{"deposit":"7163b13f-8eb4-4436-9e08-f027fa48cece"},"_deposit":{"created_by":18,"id":"44645","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44645"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044645","sets":["2812:2813:2818"]},"author_link":["76757","259"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：哺乳類の中枢概日ペースメーカー・視交叉上核（SCN）は多種・多数のニューロンから成る神経ネットワークである。しかし、SCNが強固で安定した概日振動を発振するために必要な神経ネットワークの動作原理は明らかでない。本研究では、ニューロンタイプ特異的遺伝子操作、概日行動リズム解析、SCNにおけるin vivo, ex vivoでの遺伝子発現解析などを行い、SCNのAVP産生ニューロンが安定した概日リズムの発振、周期の決定に極めて重要な役割を果たすことを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"The suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, is a network structure composed of multiple types of neurons. However, the neural mechanisms underlying the generation of robust and stable circadian oscillation by the SCN network remains unknown. We generated mice with neuron type-specific genetic manipulations and performed analyses of their behavior, gene expression in vivo and ex vivo, and so on. We found that AVP producing neurons in the SCN play a critical role in the generation of stable circadian behavioral rhythms and the determination of the circadian period.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24390052, 研究期間(年度):2012-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「概日ペースメーカー神経ネットワークの動作原理」課題番号24390052\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24390052/24390052seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050986","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20296552"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20296552","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390052/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390052/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24390052/24390052seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24390052/24390052seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-07"}],"displaytype":"detail","filename":"ME-PR-MIEDA-M-kaken 2016-4p.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MIEDA-M-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44645/files/ME-PR-MIEDA-M-kaken 2016-4p.pdf"},"version_id":"2e652251-cdad-4d79-86fb-f49ea77f343c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"概日ペースメーカー神経ネットワークの動作原理","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"概日ペースメーカー神経ネットワークの動作原理"},{"subitem_title":"Neural mechanisms underlying the circadian pacemakers","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-07"},"publish_date":"2018-06-07","publish_status":"0","recid":"44645","relation_version_is_last":true,"title":["概日ペースメーカー神経ネットワークの動作原理"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:55:53.821652+00:00"}