{"created":"2023-07-27T06:51:17.046585+00:00","id":44649,"links":{},"metadata":{"_buckets":{"deposit":"6ef2a337-d15b-4ace-9767-356259e1c110"},"_deposit":{"created_by":18,"id":"44649","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44649"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044649","sets":["2812:2813:2817"]},"author_link":["174","76763"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"当研究室では、クラスII型PI3K-C2α KO マウスは胎生期の血管形成不全により胎生致死となり、C2αが胎生期血管形成及び生後の血管恒常性維持に必要であることを見いだしていた。本研究では、内皮におけるPI(3)Pレベル調節機構を解析するために、PI(3)P脂質脱リン酸化酵素（MTM）種を同定した。更にMTM-KOマウスを作出して表現型を解析した結果、ホモKOは出生直後24時間以内に全例死亡することを見出した。以上の結果から、内皮における脂質リン酸化酵素C2aと脱リン酸化酵素MTMは強調して働き、膜小胞上でPI(3)Pレベルを調節することによって、内皮の恒常性を維持していることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Phosphatidylinositol 3-kinases (PI3Ks) are the family of lipid kinases responsible for the generation of 3’-phosphoinositides. We have recently reported that class II a-isoform PI3K (C2a) plays a crucial role in developmental and pathological angiogenesis, and is indispensable for the maintenance of the VE-cadherin-mediated EC barrier function and receptor endocytosis. These defects result in impaired vascular homeostasis under the pathophysiological conditions. In this study, we found that among myotubularin-related protein (MTMR) family members, the expression of MTMRx is relatively abundant in ECs. We found that, in HUVECs, MTMRx was localized mainly in the endosomes. Next we analyzed the phenotype of MTMRx global KO mice. MTMRx mice showed normally development but die perinatally. We conclude that C2a regulates vascular homeostasis through controlling PI(3)P+-membrane trafficking, cooperating with MTMRx in ECs.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26460292, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「血管内皮機能に必須なPI(3)P代謝酵素によるメンブレン・トラフィック制御」研究成果報告書　課題番号26460292\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460292/26460292seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050990","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80333368"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80333368","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460292/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460292/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460292/26460292seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460292/26460292seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-07"}],"displaytype":"detail","filename":"ME-PR-YOSHIOKA-K-kaken 2017-5p.pdf","filesize":[{"value":"672.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-YOSHIOKA-K-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44649/files/ME-PR-YOSHIOKA-K-kaken 2017-5p.pdf"},"version_id":"fbd64a0f-a89d-4269-af7b-65a1174946cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"血管内皮機能に必須なPI(3)P代謝酵素によるメンブレン・トラフィック制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"血管内皮機能に必須なPI(3)P代謝酵素によるメンブレン・トラフィック制御"},{"subitem_title":"Regulation of membran trafficking through PI(3)P-metabolizing enzymes in endothelial cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-07"},"publish_date":"2018-06-07","publish_status":"0","recid":"44649","relation_version_is_last":true,"title":["血管内皮機能に必須なPI(3)P代謝酵素によるメンブレン・トラフィック制御"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:34:25.348314+00:00"}