{"created":"2023-07-27T06:51:17.273366+00:00","id":44654,"links":{},"metadata":{"_buckets":{"deposit":"8613ea69-20a3-4395-8e07-a2b41ebfd1c5"},"_deposit":{"created_by":18,"id":"44654","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44654"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044654","sets":["2812:2813:2816"]},"author_link":["249","76768"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"カロリ病+先天性肝線維症の動物モデルであるPCKラットを用いた検討で,PCKラット培養胆管細胞ではmiR-125b-1-3pの発現低下とこれに関連したSmoothenedの発現亢進があり,Hedgehogシグナル伝達系の活性化による胆管細胞の過剰な増殖があることをin vitroで見出した.PCKラットにSmoothendedアンタゴニスト(cyclopamine)を投与することで,肝内胆管の拡張と腎嚢胞の形成をin vivoで有意に抑制することに成功した.以上の結果から,Hedgehogシグナル伝達系の阻害はカロリ病+先天性肝線維症の新たな治療標的となる可能性が示された.","subitem_description_type":"Abstract"},{"subitem_description":"The polycystic kidney (PCK) rat was analyzed as an animal model of Caroli’s disease with congenital hepatic fibrosis in this study. In vitro experiments revelated that PCK cholangiocytes were characterized by the reduced expression of miR-125b-1-3p, and the resultant overexpression of Smoothened and the Hedgehog signaling activation led to overgrowth of PCK cholangiocytes. In vivo administration of Smoothened antagonist (cyclopamine) significantly reduced the severity of bile duct dilatation and kidney cyst formation of the PCK rats. These results indicate that inhibition of the Hedgehog signaling represents a potential target of therapy for Caroli’s disease with congenital hepatic fibrosis.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K08342, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典:研究課題「マイクロRNAに着目したカロリ病+先天性肝線維症の新たな治療戦略」課題番号15K08342\n(KAKEN:科学研究費助成事業データベース(国立情報学研究所)) \n(https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08342/15K08342seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050995","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30324073"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30324073","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08342/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08342/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08342/15K08342seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08342/15K08342seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-15"}],"displaytype":"detail","filename":"ME-PR-SATO-Y-kaken 2018-4p.pdf","filesize":[{"value":"416.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SATO-Y-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44654/files/ME-PR-SATO-Y-kaken 2018-4p.pdf"},"version_id":"b35bf19f-15e8-4446-9ee1-c367ff4ec643"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"マイクロRNAに着目したカロリ病+先天性肝線維症の新たな治療戦略","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マイクロRNAに着目したカロリ病+先天性肝線維症の新たな治療戦略"},{"subitem_title":"Novel therapeutic approaches for biliary cystogenesis of Caroli's disease with congenital hepatic fibrosis based on the analysis of microRNAs","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-15"},"publish_date":"2019-04-15","publish_status":"0","recid":"44654","relation_version_is_last":true,"title":["マイクロRNAに着目したカロリ病+先天性肝線維症の新たな治療戦略"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:01:04.850263+00:00"}