{"created":"2023-07-27T06:51:17.318100+00:00","id":44655,"links":{},"metadata":{"_buckets":{"deposit":"60f7fb8a-a803-4e9d-9a48-99fb928aa074"},"_deposit":{"created_by":18,"id":"44655","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44655"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044655","sets":["2812:2813:2820"]},"author_link":["249","76768"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-28","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"カロリ病＋先天性肝線維症の動物モデルとして確立されたPCKラットを用い、肝胆管病変の形成におけるPI3K/Akt/mTORを介した細胞内シグナル伝達の関与、ならびにその阻害剤の治療への応用性を検討した．PCKラット培養胆管細胞を用いた検討で、NVP-BEZ235（PI3K + mTOR阻害剤）は細胞増殖と嚢胞形成を抑制し、これは培養胆管細胞のアポトーシス抑制とオートファジー誘導を伴っていた．In vivoでPCKラットにNVP-BEZ235を投与すると、PCKラットの胆管拡張と肝線維化を有意に軽減させることが可能であった．","subitem_description_type":"Abstract"},{"subitem_description":"Using the PCK rat, an animal model of Caroli's disease with congenital hepatic fibrosis, the involvement of the PI3K/Akt/mTOR pathway in biliary dysgenesis was examined in terms of therapeutic application. NVP-BEZ235 (an inhibitor of PI3K and mTOR) significantly inhibited cell proliferative activity and cystic growth of the cultured PCK cholangiocytes, which was accompanied by inhibition of apoptosis and induction of autophagy in the cells. In vivo, administration of NVP-BEZ235 significantly improved dilatation of intrahepatic bile ducts and liver fibrosis of the PCK rat.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23590392, 研究期間(年度):2011-2013","subitem_description_type":"Other"},{"subitem_description":"出典：「カロリ病＋先天性肝線維症の新規薬物療法の探索: 動物モデルPCKラットを用いて」研究成果報告書　課題番号23590392\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590392/23590392seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050996","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30324073"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30324073","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590392/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590392/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590392/23590392seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590392/23590392seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-07"}],"displaytype":"detail","filename":"ME-PR-SATO-Y-kaken 2014-4p.pdf","filesize":[{"value":"165.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SATO-Y-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44655/files/ME-PR-SATO-Y-kaken 2014-4p.pdf"},"version_id":"54f26ff6-5008-4b3e-bc0b-4f016b1e3dba"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"カロリ病＋先天性肝線維症の新規薬物療法の探索: 動物モデルPCKラットを用いて","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"カロリ病＋先天性肝線維症の新規薬物療法の探索: 動物モデルPCKラットを用いて"},{"subitem_title":"Therapeutic approaches for biliary dysgenesis of the PCK rat, an animal model of Caroli's desease with congenital hepatic fibrosis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-07"},"publish_date":"2018-06-07","publish_status":"0","recid":"44655","relation_version_is_last":true,"title":["カロリ病＋先天性肝線維症の新規薬物療法の探索: 動物モデルPCKラットを用いて"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:19:34.257513+00:00"}