{"created":"2023-07-27T06:51:17.363298+00:00","id":44656,"links":{},"metadata":{"_buckets":{"deposit":"a1cbcd4e-8bf1-44e0-a247-9677ff1f4b66"},"_deposit":{"created_by":18,"id":"44656","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44656"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044656","sets":["2812:2813:2823"]},"author_link":["249","76768"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2009-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"上皮・間葉変換機構(epithelial-mesenchymal transition,EMT)は癌の浸潤・転移に深く関与している。本研究は胆管癌の浸潤・転移におけるEMTの関与を明らかにすることを目的とした。培養胆管癌細胞と胆管癌の外科的切除材料を用いた検討により、胆管癌の浸潤・転移にはtransforming growth factor-・1とSnailを介した癌細胞のEMTが深く関与しており、予後不良の難治性癌である胆管癌の増悪因子であることが示された。","subitem_description_type":"Abstract"},{"subitem_description":"Epithelial-mesenchymal transition (EMT) is an important mechanism behind the initiation of cancer invasion and metastasis. This study was performed to clarify the involvement of EMT in the progression of cholangiocarcinoma. Studies using cholangiocarcinoma cell lines and surgically resected specimens of cholangiocarcinoma demonstrated that EMT induced by transforming growth factor-β1/Snail activation was closely associated with the aggressive growth of cholangiocarcinoma, resulting in a poor prognosis.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「胆管癌の浸潤・転移に関する分子病理学的研究: 癌細胞の上皮・間葉変換機構に着目して」課題番号21790346\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790346/21790346seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050997","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30324073"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30324073","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790346/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790346/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790346/21790346seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790346/21790346seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-07"}],"displaytype":"detail","filename":"ME-PR-SATO-Y-kaken 2011-4p.pdf","filesize":[{"value":"171.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SATO-Y-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44656/files/ME-PR-SATO-Y-kaken 2011-4p.pdf"},"version_id":"c6d93866-cb11-4933-b32b-6ee6b6365eec"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胆管癌の浸潤・転移に関する分子病理学的研究: 癌細胞の上皮・間葉変換機構に着目して","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胆管癌の浸潤・転移に関する分子病理学的研究: 癌細胞の上皮・間葉変換機構に着目して"},{"subitem_title":"Molecular pathology of the mechanism of the invasion and metastasis of cholangiocacinoma:  From the aspects of epithelial-mesenchymal transition","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-07"},"publish_date":"2018-06-07","publish_status":"0","recid":"44656","relation_version_is_last":true,"title":["胆管癌の浸潤・転移に関する分子病理学的研究: 癌細胞の上皮・間葉変換機構に着目して"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:17:33.358695+00:00"}