{"created":"2023-07-27T06:51:19.253859+00:00","id":44701,"links":{},"metadata":{"_buckets":{"deposit":"1339fd4b-66cf-4b86-b16b-3fa437239268"},"_deposit":{"created_by":18,"id":"44701","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44701"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044701","sets":["2812:2813:2820"]},"author_link":["76997","76998"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takayasu, Tatsunori"}],"nameIdentifiers":[{"nameIdentifier":"76998","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80154912","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80154912"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"合成麻薬MDMAについて，覚醒剤メタンフェタミン(MA)と構造がよく似ていることから，生体の反応は覚醒剤の反応とどこが同じで，何が異なるのかを明らかにする目的で，合成麻薬MDMAとMA とをマウスに長期投与し，脳や心臓における各種因子について包括的に解析した。その結果，マウスの体重はいすれも生食水を投与したブランクに比較し10-20日減少傾向を示した。その後はブランクとほぼ同じ比率で増加した。脳および心臓試料から包括的mRNA 解析を行った結果，脂肪や脂肪酸代謝因子，サイトカイン，転写因子，翻訳因子など多岐にわたる因子の変動が見られた。これらの結果は今後の解析の基礎となる。","subitem_description_type":"Abstract"},{"subitem_description":"MDMA is a synthetic narcotic, which is resembled to methamphetamine (MA) structure. The aim of this study is clear the differences of biological functions from MDMA and MA. MDMA and MA were separately injected to mice once two days during 51 days as well as saline for a blank experiment. Mice weights for MDMA or MA were decreased to those of a blank group for 10-20 days. Then mice weights for MDMA and MA were increased same rate as the blank group. Comprehensive mRNA analyses with the brain and heart showed changes of metabolic factors for lipids and fatty acids, cytokines, transcription factors, translations factors, and others. These results are fundamental to the next experiment.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23590845, 研究期間(年度):2011-2013","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「合成麻薬MDMAによる毒性機構の包括的解析」課題番号23590845\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590845/23590845seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051042","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80154912"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80154912","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590845/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590845/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590845/23590845seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590845/23590845seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高安, 達典"}],"nameIdentifiers":[{"nameIdentifier":"76997","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80154912","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80154912"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-14"}],"displaytype":"detail","filename":"ME-PR-TAKAYASU-T-kaken 2014-5p.pdf","filesize":[{"value":"141.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAKAYASU-T-kaken 2014-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44701/files/ME-PR-TAKAYASU-T-kaken 2014-5p.pdf"},"version_id":"efa7e9d6-cba4-455c-9350-df05386a316a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"合成麻薬MDMAによる毒性機構の包括的解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"合成麻薬MDMAによる毒性機構の包括的解析"},{"subitem_title":"Comprehensive analysis for biological toxicity with synthetic narcotic MDMA","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-14"},"publish_date":"2018-06-14","publish_status":"0","recid":"44701","relation_version_is_last":true,"title":["合成麻薬MDMAによる毒性機構の包括的解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:51:42.497279+00:00"}