{"created":"2023-07-27T06:51:19.434584+00:00","id":44705,"links":{},"metadata":{"_buckets":{"deposit":"30176633-bd9b-475b-848f-deb6cceef191"},"_deposit":{"created_by":18,"id":"44705","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44705"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044705","sets":["2812:2813:2820"]},"author_link":["77002","77003"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-05","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヘムオキシゲナーゼ１（HO-1）はヘム代謝における律速酵素で、生体に対する抗酸化作用示す。１９９９年にわれわれは世界で初めて「ヒトHO-1欠損」症例 を発見したが、その後２０１１年に第２例目、さらに本研究期間に入って、３例の追加症例報告があった。５例とも全身性炎症、無脾症、血管内皮障害、高血圧を発症し、溶血性貧血、低ビリルビン血症、血小板増加、腎障害を認めた。以上から、HO-1欠損症は新たな全身性炎症疾患概念を確立するものであることを示唆する。","subitem_description_type":"Abstract"},{"subitem_description":"Heme oxygenase-1(HO-1) is the rate-limiting enzyme to metabolyze heme, showing antioxidant effects. In 1999, we reported the first case of human HO-1 deficiency. After the 2nd case was discovered in 2011, the 3 subsequent cases have been reported so far. All 5 patients with HO-1 deficiency were characterized by recalcitrant systemic inflammation, asplenia, microangiopathy and hypertention. Clinical data show hemolytic anemia with low serum bilirubin, thrombocytosis and evidences of renal tissue injury. From these data we would like to introduce HO-1 deficiency as a novel autoinflammatory disease.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23591531, 研究期間(年度):2011-2013","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ヒトヘムオキシゲナーゼ（HO）-1欠損症の第2例目発見: HO-1の機能的本質」課題番号23591531\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591531/23591531seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051046","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50019973"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50019973","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591531/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591531/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591531/23591531seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591531/23591531seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-14"}],"displaytype":"detail","filename":"ME-PR-KOIZUMI-S-kaken 2014-6p.pdf","filesize":[{"value":"188.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KOIZUMI-S-kaken 2014-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44705/files/ME-PR-KOIZUMI-S-kaken 2014-6p.pdf"},"version_id":"e5f0e38d-7755-4ed1-b056-6a9607f4b9d7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒトヘムオキシゲナーゼ（HO）-1欠損症の第2例目発見: HO-1の機能的本質","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒトヘムオキシゲナーゼ（HO）-1欠損症の第2例目発見: HO-1の機能的本質"},{"subitem_title":"The discovery of the ssecond case of human hemp oxygenase-1 deficiency: biological evidence of HO-1 enzyme","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-14"},"publish_date":"2018-06-14","publish_status":"0","recid":"44705","relation_version_is_last":true,"title":["ヒトヘムオキシゲナーゼ（HO）-1欠損症の第2例目発見: HO-1の機能的本質"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:19:07.120244+00:00"}