{"created":"2023-07-27T06:51:19.479442+00:00","id":44706,"links":{},"metadata":{"_buckets":{"deposit":"161bd21f-03c3-4a8a-974d-553665b94add"},"_deposit":{"created_by":18,"id":"44706","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44706"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044706","sets":["2812:2813:2823"]},"author_link":["77002","52683"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヘムオキシゲナーゼ1(HO-1)はヘムを一酸化炭素(CO)とビリルビンとフェリチン(Feより誘導される)に代謝する律則酵素である。われわれが世界で初めて発見した「ヒトHO-1欠損」症例(1999)は2歳頃からの全身性慢性炎症が増悪し6歳で死亡した。本症例及びその後海外で発見された症例の詳細な病態解析とin vitro実験的研究によって、HO-1欠損症の臨床病態が明らかにされるとともに、HO-1の造血系および感染免疫系調節機構における生理的重要性が強く認識された。","subitem_description_type":"Abstract"},{"subitem_description":"Heme oxygenase-1(HO-1) is the rate-limiting enzyme that adds an oxygen molecule to the porphyrin ring of heme, thereby catalyzing to biliverdin, free iron (finally to bilirubin and ferritin, respectively) and carbon monoxide. In 1999, the first case of human HO-1 deficiency was reported by Yachie et al. at our Department of Pediatrics, Kanazawa University Hospital The male patient suffered from generalized severe inflammation since the age of 2, and died at 6 years of age. Quite recently the 2nd case was discovered and reported. Aggressive clinical and patho-physiological studies about these two cases and some experimental investigations have shown detailed clinical findings of HO-1 deficiency and revealed that the HO-1 enzyme is crucial for development and growth of human beings on hematopoiesis, immunological system and the defense mechanism against inflammation and oxidative stresses.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「ヘムオキシゲナーゼ1の造血系および免疫系調節機構における生理的重要性」課題番号20591275\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591275/20591275seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051047","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50019973"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50019973","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591275/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591275/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591275/20591275seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591275/20591275seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-14"}],"displaytype":"detail","filename":"ME-PR-KOIZUMI-S-kaken 2011-5p.pdf","filesize":[{"value":"223.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KOIZUMI-S-kaken 2011-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44706/files/ME-PR-KOIZUMI-S-kaken 2011-5p.pdf"},"version_id":"1ec82a02-6059-4dbb-a0cb-1ed615b2bb80"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヘムオキシゲナーゼ1の造血系および免疫系調節機構における生理的重要性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヘムオキシゲナーゼ1の造血系および免疫系調節機構における生理的重要性"},{"subitem_title":"Physiological importance of hemo oxygenase-1 on hemopoiesis, inflammation and immunology system","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-14"},"publish_date":"2018-06-14","publish_status":"0","recid":"44706","relation_version_is_last":true,"title":["ヘムオキシゲナーゼ1の造血系および免疫系調節機構における生理的重要性"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:17:30.728754+00:00"}