{"created":"2023-07-27T06:51:20.154773+00:00","id":44721,"links":{},"metadata":{"_buckets":{"deposit":"563744d6-8de8-47e0-8146-a2a6f72abcf3"},"_deposit":{"created_by":18,"id":"44721","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44721"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044721","sets":["2812:2813:2821"]},"author_link":["310","69907"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-14","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2010-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は微小環境下において、がん細胞が分泌するTGF-βが腹膜中皮細胞 (HPMC)におよぼす影響を検討した。TGF-βによって活性化したHPMC (a-HPMC)は間葉系細胞様に形質転換し (EMT)、浸潤能や増殖能を獲得することを明らかにした。TGF-βによって誘導されるEMT様変化は増殖抑制を来さない低濃度paclitaxelによって阻害可能であり、そのメカニズムとしてSmad2のリン酸化を抑制することを明らかにした。さらに、マウス背部にMKN45とa-HPMCを共に培養したものを移植したところ、腫瘍の線維化をも誘導することを証明した。","subitem_description_type":"Abstract"},{"subitem_description":"We investigated whether TGF-β derived from cancer cells in the peritoneal microenvironment activates human peritoneal mesothelial cells (HPMCs), leading to the progression and fibrosis of gastric cancer. We found that activated HPMCs (a-HPMCs) became more invasive and up-regulated proliferation of human gastric cancer-derived MKN45 cells following direct cell-cell contact. These EMT-like changesof HPMC were suppressed under 5nM of paclitaxel pretreatment by inhibiting Smad2 phosphorylation. To measure the effects of co-culture in vivo, we developed a mouse xenograft model. The largest tumors were observed in mice given MKN45 cells that had been co-cultured with a-HPMCs. Additionaly, these tumors contained HPMC-derived fibrous tissue.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22591451, 研究期間(年度):2010-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「腹膜播種発生に関わる腹膜中皮細胞の間葉系形質転換と造腫瘍性についての実験的検討」課題番号22591451\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22591451/22591451seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051062","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10301194"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10301194","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591451/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591451/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22591451/22591451seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22591451/22591451seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-14"}],"displaytype":"detail","filename":"ME-PR-FUSHIDA-Y-kaken 2013-4p.pdf","filesize":[{"value":"385.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-FUSHIDA-Y-kaken 2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44721/files/ME-PR-FUSHIDA-Y-kaken 2013-4p.pdf"},"version_id":"57e7b666-7799-458b-9ce2-428702eca78f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"腹膜播種発生に関わる腹膜中皮細胞の間葉系形質転換と造腫瘍性についての実験的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腹膜播種発生に関わる腹膜中皮細胞の間葉系形質転換と造腫瘍性についての実験的検討"},{"subitem_title":"Human Peritoneal Mesothelial Cell play important roles in the development of peritoneal metastasis by its EMT change","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-14"},"publish_date":"2018-06-14","publish_status":"0","recid":"44721","relation_version_is_last":true,"title":["腹膜播種発生に関わる腹膜中皮細胞の間葉系形質転換と造腫瘍性についての実験的検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:41:18.298168+00:00"}