{"created":"2023-07-27T06:51:20.199430+00:00","id":44722,"links":{},"metadata":{"_buckets":{"deposit":"d3744bc8-2318-47c6-bbfb-eebb547eced7"},"_deposit":{"created_by":18,"id":"44722","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44722"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044722","sets":["2812:2813:2825"]},"author_link":["310","69907"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2007-2008","bibliographic_titles":[{"bibliographic_title":"平成20(2008)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2008 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アンギオテンシンIIを介した細胞の増殖や間質の線維化および抗アポトーシスが胃癌の腹膜播種の成立に関与していると予想し、そのメカニズムの解明および治療への応用が可能か否かを検討した。その結果、胃癌組織中のアンギオテンシンII濃度は正常胃組織と比較して有意に高濃度であり、腫瘍周囲に浸潤した肥満細胞から発現されるmast cell tryptaseによって生成されることが明らかとなった。また、アンギオテンシンIIの受容体であるAT1は胃癌原発巣や腹膜播種巣に高率に発現していた。肥満細胞の機能を抑制し、かつTGFbの機能も抑制するトラニラストおよびAT1アンタゴニストのcandesartanを用いてマウス腹膜播種モデルにおいて播種が抑制されることを解明した。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19591534, 研究期間(年度):2007-2008","subitem_description_type":"Other"},{"subitem_description":"出典：「胃癌腹膜播種におけるTGFβおよびアンギオテンシン系を介した分子標的治療の開発」研究成果報告書　課題番号19591534\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19591534/19591534seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051063","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10301194"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10301194","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591534/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591534/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19591534/19591534seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19591534/19591534seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-14"}],"displaytype":"detail","filename":"ME-PR-FUSHIDA-Y-kaken 2009-5p.pdf","filesize":[{"value":"242.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-FUSHIDA-Y-kaken 2009-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44722/files/ME-PR-FUSHIDA-Y-kaken 2009-5p.pdf"},"version_id":"301603d1-a8ce-4209-94d8-04175eac1b1f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胃癌腹膜播種におけるTGFβおよびアンギオテンシン系を介した分子標的治療の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胃癌腹膜播種におけるTGFβおよびアンギオテンシン系を介した分子標的治療の開発"},{"subitem_title":"Development of molecular targeted therapy via TGFβ and angiotensin system for peritoneal dissemination of gastric cancer","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2825"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-14"},"publish_date":"2018-06-14","publish_status":"0","recid":"44722","relation_version_is_last":true,"title":["胃癌腹膜播種におけるTGFβおよびアンギオテンシン系を介した分子標的治療の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:14:54.991272+00:00"}