{"created":"2023-07-27T06:51:20.333532+00:00","id":44725,"links":{},"metadata":{"_buckets":{"deposit":"22b9cc02-6bdd-4479-b9d1-5dda9d1556c8"},"_deposit":{"created_by":18,"id":"44725","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44725"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044725","sets":["2812:2813:2824"]},"author_link":["115","22513"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2007-2009","bibliographic_titles":[{"bibliographic_title":"平成21(2009)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2009 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"^<131>I-MIBG内用療法の治療効果を、他の有効な治療法のない悪性神経内分泌腫瘍患者において高めることを目的とした。担癌マウスにおいて投与ルートの検討を行った結果、体腔内播種した状況では、体腔内投与の有効性が確認された。臨床では、従来国内で行われていなかった、全身線量計算を元に大投与量内用療法の意義を示した。正確な部位同定と線量計算のため、シンチグラム断層撮影(SPECT)情報とCT情報の融合像での病巣評価を行い、高精度で可能であることを確認した。","subitem_description_type":"Abstract"},{"subitem_description":"This study aimed to enhance therapeutic efficacy of targeted radionuclide therapy with ^<131>I-MIRG for malignant refractory neuroendcrine tumors. Locoregi onal administration of ^<131>I-MTRG was found to better prolong survival of mice with disseminated tumors than systemic administration. Feasibility of high-dose therapy based on dosimetric analysis was determined firstly in Japan. Fusion images of single photon emission computed tomography (SPFCT) and x-ray CT enabled precise detection of lesions and provided information for accurate dosimetry.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19390317, 研究期間(年度):2007-2009","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「悪性神経内分泌腫瘍に対する血管新生阻害下内用療法: 基礎研究から臨床応用へ」課題番号19390317\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19390317/19390317seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051066","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20281024"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20281024","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390317/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390317/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19390317/19390317seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19390317/19390317seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-14"}],"displaytype":"detail","filename":"ME-PR-KINUYA-S-kaken 2011-4p.pdf","filesize":[{"value":"214.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KINUYA-S-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44725/files/ME-PR-KINUYA-S-kaken 2011-4p.pdf"},"version_id":"a68b3b45-272b-49cb-8fd0-c57155727c70"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"悪性神経内分泌腫瘍に対する血管新生阻害下内用療法: 基礎研究から臨床応用へ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"悪性神経内分泌腫瘍に対する血管新生阻害下内用療法: 基礎研究から臨床応用へ"},{"subitem_title":"Targeted radionuclide therapy for malignant neuroendcrine tumors combined with antiangiogenic therapy: from bench to bedsaide","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2824"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-14"},"publish_date":"2018-06-14","publish_status":"0","recid":"44725","relation_version_is_last":true,"title":["悪性神経内分泌腫瘍に対する血管新生阻害下内用療法: 基礎研究から臨床応用へ"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:15:11.766525+00:00"}