{"created":"2023-07-27T06:51:21.142940+00:00","id":44743,"links":{},"metadata":{"_buckets":{"deposit":"0ce394fa-ccd4-4e72-b5a1-eec6322e35ff"},"_deposit":{"created_by":18,"id":"44743","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44743"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044743","sets":["2812:2813:2819"]},"author_link":["77179","53"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2013-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々が見出したヌクレオチド除去修復阻害化合物(NERi)が、シスプラチンの抗腫瘍作用増強剤となりうるか検討を行った。まず、胃癌由来KKLS細胞および卵巣癌由来A2780細胞を用いたコロニーアッセイで、NERiは2~3倍の増強を示すことがわかった。また、シスプラチンで誘発される1,2-GpG架橋損傷の修復が、NERiの前処理により阻害されることを確認した。そこで、マウス肺癌由来LLC細胞をC57BL/6マウスに移植し、シスプラチンとNERiとの併用効果を調べたところ、シスプラチン単独処理に比べて有意に高い抗腫瘍作用が観察された。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we have analyzed whether a small-molecule inhibitor of nucleotide excision repair (NERi) we recently found can potentiate the cytotoxic effects of cisplatin in cancer cells. The clonogenic survival assay revealed that NERi treatment increases the cisplatin-sensitivity of KKLS stomach cancer cell lines and A2780 ovarian cancer cell lines 2-3 fold. Using an immunoassay with damage-specific antibody, we showed that the removal of cisplatin-induced DNA intrastrand crosslinks is markedly attenuated by NERi treatment. Furthermore, in vivo experiments using murine Lewis lung carcinoma and C57BL/6 mice revealed that a combination of cisplatin and NERi significantly suppresses tumor growth, compared with cisplatin alone.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25640089, 研究期間(年度):2013-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典:研究課題「シスプラチン抵抗性関連因子ERCC1の分解を誘導する新規低分子化合物の解析」課題番号25640089\n(KAKEN:科学研究費助成事業データベース(国立情報学研究所))\n(https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25640089/25640089seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051084","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60192340"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60192340","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25640089/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25640089/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25640089/25640089seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25640089/25640089seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-18"}],"displaytype":"detail","filename":"PH-PR-MATSUNAGA-T-kaken 2015-4p.pdf","filesize":[{"value":"317.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-MATSUNAGA-T-kaken 2015-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44743/files/PH-PR-MATSUNAGA-T-kaken 2015-4p.pdf"},"version_id":"424ceeee-bab0-4726-8e01-aea1969fedea"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"シスプラチン抵抗性関連因子ERCC1の分解を誘導する新規低分子化合物の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"シスプラチン抵抗性関連因子ERCC1の分解を誘導する新規低分子化合物の解析"},{"subitem_title":"Analysis of a novel small-molecule compound inducing the degradation of a cisplatin resistance-related factor ERCC1","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-18"},"publish_date":"2018-06-18","publish_status":"0","recid":"44743","relation_version_is_last":true,"title":["シスプラチン抵抗性関連因子ERCC1の分解を誘導する新規低分子化合物の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:43:30.296076+00:00"}