{"created":"2023-07-27T06:51:21.187184+00:00","id":44744,"links":{},"metadata":{"_buckets":{"deposit":"893f1f06-a3e3-43d5-acee-eee997cd065f"},"_deposit":{"created_by":18,"id":"44744","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44744"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044744","sets":["2812:2813:2818"]},"author_link":["77179","53"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-30","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2013-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は、これまでにヒト細胞のヌクレオチド除去修復反応を阻害する低分子化合物を発見し、ERCC1-XPFのプロテアソーム依存的分解誘導が原因であることを明らかにしている。本研究では、この分解誘導の詳細なメカニズムを明らかにすべく、この反応に関わる因子の同定を試み、２種のポリユビキチン化関連因子を同定した。また、100種以上の構造類縁体を用いて活性を比較し、構造活性相関を明らかにした。一方、新たな化合物ライブラリーを用いたスクリーニングも実施したが、上記化合物と同レベルの高い阻害活性を示す化合物は得られなかった。","subitem_description_type":"Abstract"},{"subitem_description":"We recently identified a small-molecule inhibitor (NERi) of nucleotide excision repair in human cells, which induces proteasomal degradation of one of core NER factors, ERCC1-XPF. In this study, we have tried to uncover the detailed mechanism underlying the loss of ERCC1-XPF heterodimer after NERi treatment. We have finally identified two cellular proteins possibly involved in the proteosomal degradation of ERCC1-XPF. We have also determined a structure-activity relationship of NERi by comparing the activity of more than 100 derivatives. On the other hand, we could find no further compounds showing comparably high NER-inhibition activity with NERi after screening of another public chemical library.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25281017, 研究期間(年度):2013-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ケミカルバイオロジーを利用したヒトヌクレオチド除去修復機構の解析」課題番号25281017\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25281017/25281017seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051085","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60192340"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60192340","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25281017/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25281017/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25281017/25281017seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25281017/25281017seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-18"}],"displaytype":"detail","filename":"PH-PR-MATSUNAGA-T-kaken 2016-4p.pdf","filesize":[{"value":"168.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-MATSUNAGA-T-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44744/files/PH-PR-MATSUNAGA-T-kaken 2016-4p.pdf"},"version_id":"b55d4faf-c913-4889-bbd4-486bac0d1b3e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ケミカルバイオロジーを利用したヒトヌクレオチド除去修復機構の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ケミカルバイオロジーを利用したヒトヌクレオチド除去修復機構の解析"},{"subitem_title":"Application of chemical biology to a mechanistic study of human necleotide excision repair","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-18"},"publish_date":"2018-06-18","publish_status":"0","recid":"44744","relation_version_is_last":true,"title":["ケミカルバイオロジーを利用したヒトヌクレオチド除去修復機構の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:55:50.399741+00:00"}