{"created":"2023-07-27T06:51:22.036280+00:00","id":44760,"links":{},"metadata":{"_buckets":{"deposit":"9d998967-bf64-49c9-9099-8f4f0ffec755"},"_deposit":{"created_by":18,"id":"44760","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44760"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044760","sets":["2812:2813:2817"]},"author_link":["2653","77197"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"余剰造血幹前駆細胞（HSPC）のマーカーであるCXCR4陽性のHSCPを活性化できれば、再生不良性貧血（再不貧）患者の造血機能を改善させられる可能性がある。免疫不全マウスの骨髄内にヒトCD34(+)細胞を移植したところ、3.3-20.4%のヒトCD45陽性細胞の再生を確認した。６pLOH陽性の再不貧患者単球由来iPS細胞からHSPCを誘導し、同じマウスに移植したところ、患者体内で優勢であった6pLOH(+)HSPCのCXCR4(+)細胞割合(平均10.2%)は野生型（50.7％）に比べて有意に低値であった。野生型CXCR4(+)HSPCをin vivoで活性化させる方法を現在検討中である。","subitem_description_type":"Abstract"},{"subitem_description":"A chemokine receptor CXCR4 is preferentially expressed by redundant hematopoietic stem/progenitor cells (HSPCs) that do not contribute to hematopoiesis. Stimulation of residual CXCR4(+) HSPCs may restore hematopoietic function of patients with acquired aplastic anemia (AA). First, we optimized method of engrafting an immune-deficient mouse (BRGS mouse) with cord-blood CD34(+) cells using intra-bone marrow injection, and confirmed the presence of human CD45(+) cells that accounted for 3.3-20.4% of the various tissue-derived cells. Next, we induced HSPCs from iPS cells that were generated from monocytes of AA patients possessing 6pLOH(+) leukocytes, which were predominant in the patients’ blood, as a result of uniparental disomy, and injected the HSPCs to the same mice. Regenerating human 6pLOH(+)CD34(+) cells in the mice expressed CXCR4 to a significantly lesser degree (mean 10.2%) than did 6pLOH(-)CD34(+) cells. We are currently exploring a method to activate CXCR4(+) HSPCs in vivo.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K15360, 研究期間(年度):2015-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「骨髄不全におけるCXCR4陽性造血幹細胞を標的とした新規治療法の開発」研究成果報告書　課題番号15K15360\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15360/15K15360seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051101","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70217660"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70217660","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15360/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15360/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15360/15K15360seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15360/15K15360seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-18"}],"displaytype":"detail","filename":"ME-PR-NAKAO-S-kaken 2017-4p.pdf","filesize":[{"value":"348.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAKAO-S-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44760/files/ME-PR-NAKAO-S-kaken 2017-4p.pdf"},"version_id":"88210b33-f9f7-4e93-93e4-eb49c495db1e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"骨髄不全におけるCXCR4陽性造血幹細胞を標的とした新規治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"骨髄不全におけるCXCR4陽性造血幹細胞を標的とした新規治療法の開発"},{"subitem_title":"Development of a new therapy targeting CXCR4+ hematopoietic stem cells in patients with bone marrow failure","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-18"},"publish_date":"2018-06-18","publish_status":"0","recid":"44760","relation_version_is_last":true,"title":["骨髄不全におけるCXCR4陽性造血幹細胞を標的とした新規治療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:31:48.609739+00:00"}