@article{oai:kanazawa-u.repo.nii.ac.jp:00044770,
 author = {Yuki, Midori},
 issue = {1},
 journal = {金沢大学十全医学会雑誌, Journal of the Juzen Medical Society},
 month = {Mar},
 note = {Purpose: Carvedilol, a nonselective beta-adrenoceptor and selective alpha 1-adrenoceptor blocker, has high efficacy and is widely used in hypertensive and/or cardiac failure patients. However, few studies have examined the effects of carvedilol on septic shock. The present study evaluated the effects of carvedilol pretreatment in cecal ligation and puncture (CLP)-induced septic shock in rats. 
 Methods: Male Sprague Dawley rats (n = 90) were randomly assigned to one of the following three groups (n = 30 per group): control group (no medication), high-dose carvedilol group (10 mg/kg/day, orally administered for 5 days), and low-dose carvedilol group (2 mg/kg/day, orally administered for 5 days). Septic shock was induced by CLP, and the animals received no other therapies. Mortality was calculated for 5 days after CLP. Arterial blood gases and plasma cytokine concentrations were measured in 36 additional male rats 12 hr after CLP. 
 Results: Mortality rates 5 days after CLP were 76.7%, 86.7%, and 86.7% in the control, high-dose, and low-dose groups, respectively; there were no significant differences among the three groups. Furthermore, observed decreases in base excess, increases in lactate concentrations, and increases in cytokine concentrations in the carvedilol-treated groups did not differ from those in the control group. 
 Conclusions: The present findings indicate that orally administered carvedilol has no beneficial effects on mortality and inflammatory responses in CLP-induced septic shock in rats, suggesting that carvedilol may not contribute to recovery from septic shock.},
 pages = {10--15},
 title = {Effects of carvedilol pretreatment on mortality and inflammatory responses to septic shock induced by cecal ligation and puncture in rats},
 volume = {127},
 year = {2018}
}