{"created":"2023-07-27T06:51:22.432875+00:00","id":44770,"links":{},"metadata":{"_buckets":{"deposit":"2933ff0d-53fa-4e54-9d9c-b04b2440f05d"},"_deposit":{"created_by":3,"id":"44770","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"44770"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044770","sets":["1132:1137:1270:3574"]},"author_link":["77209"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"15","bibliographicPageStart":"10","bibliographicVolumeNumber":"127","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"},{"bibliographic_title":"Journal of the Juzen Medical Society","bibliographic_titleLang":"en"}]}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Carvedilol, a nonselective beta-adrenoceptor and selective alpha 1-adrenoceptor blocker, has high efficacy and is widely used in hypertensive and/or cardiac failure patients. However, few studies have examined the effects of carvedilol on septic shock. The present study evaluated the effects of carvedilol pretreatment in cecal ligation and puncture (CLP)-induced septic shock in rats. \n Methods: Male Sprague Dawley rats (n = 90) were randomly assigned to one of the following three groups (n = 30 per group): control group (no medication), high-dose carvedilol group (10 mg/kg/day, orally administered for 5 days), and low-dose carvedilol group (2 mg/kg/day, orally administered for 5 days). Septic shock was induced by CLP, and the animals received no other therapies. Mortality was calculated for 5 days after CLP. Arterial blood gases and plasma cytokine concentrations were measured in 36 additional male rats 12 hr after CLP. \n Results: Mortality rates 5 days after CLP were 76.7%, 86.7%, and 86.7% in the control, high-dose, and low-dose groups, respectively; there were no significant differences among the three groups. Furthermore, observed decreases in base excess, increases in lactate concentrations, and increases in cytokine concentrations in the carvedilol-treated groups did not differ from those in the control group. \n Conclusions: The present findings indicate that orally administered carvedilol has no beneficial effects on mortality and inflammatory responses in CLP-induced septic shock in rats, suggesting that carvedilol may not contribute to recovery from septic shock. ","subitem_description_type":"Abstract"}]},"item_7_heading_33":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_banner_headline":"原著","subitem_heading_language":"ja"},{"subitem_heading_banner_headline":"Originals","subitem_heading_language":"en"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051111","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢大学十全医学会 "}]},"item_7_publisher_19":{"attribute_name":"出版者（別名）","attribute_value_mlt":[{"subitem_publisher":"The Juzen Medical Society Kanazawa University"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397 ","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yuki, Midori"}],"nameIdentifiers":[{"nameIdentifier":"77209","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-01"}],"displaytype":"detail","filename":"AN00044397-127-1-10-15.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"AN00044397-127-1-10-15.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44770/files/AN00044397-127-1-10-15.pdf"},"version_id":"55795d01-03fe-41c5-ac38-22211e5b7b1e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"beta-blocker","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"carvedilol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sepsis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"shock","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cytokine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of carvedilol pretreatment on mortality and inflammatory responses to septic shock induced by cecal ligation and puncture in rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of carvedilol pretreatment on mortality and inflammatory responses to septic shock induced by cecal ligation and puncture in rats"}]},"item_type_id":"7","owner":"3","path":["3574"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-18"},"publish_date":"2018-06-18","publish_status":"0","recid":"44770","relation_version_is_last":true,"title":["Effects of carvedilol pretreatment on mortality and inflammatory responses to septic shock induced by cecal ligation and puncture in rats"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T17:02:56.536101+00:00"}