{"created":"2023-07-27T06:51:23.003098+00:00","id":44786,"links":{},"metadata":{"_buckets":{"deposit":"1217cbc0-7504-440e-bc37-bf19e0d225b3"},"_deposit":{"created_by":18,"id":"44786","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44786"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044786","sets":["2812:2813:2820"]},"author_link":["23691","44"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2011-04-01 - 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アレルギー性疾患の原因については、胎児期あるいは小児期の前半に最も頻繁に感染するRespiratory syncytialウイルスなどのウイルスの関与がよく知られるようになったが、その病態の背景である感受性遺伝子との相互作用はよく知られていない。妊娠モデルマウスの児の脾臓細胞のIL4RA遺伝子におけるCpG部位のメチル化と感染の関係が出産直後において認められた。疫学研究では、臍帯血単核球のIL4RAにおけるCpG部位のメチル化がハウスダスト感作による喘息との関係において認められた。これらの結果から、出生直後の児において感染が成立するとともにアレルギー関連の遺伝子が発現していると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"The infection of virus such as respiratory syncytial virus is involved in pathogenesis of allergy during prenatal and postnatal infants, although the interaction between candidate genes and virus infection remains to be elucidated. We demonstrated hypomethylation of CpG islands produced by virus infection in IL4RA gene in splenic cells for postpartum infants from pregnant model mouse. Epidemiologic study showed the hypomethylation of CpG islands in in IL4RA gene in monocytes in cord blood of pregnant patients with asthma sensitized by house dust. These results suggest expression of IL4RA gene in just new born infants is produced by infection of RS virus.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23390160, 研究期間(年度):2011-04-01 - 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「アレルギー疾患エピジェネティクスにおけるウイルス感染の役割解明とその予防法の開発」課題番号23390160\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390160/23390160seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051125","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30231476"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30231476","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390160/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390160/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390160/23390160seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390160/23390160seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-21"}],"displaytype":"detail","filename":"ME-PR-NAKAMURA-H-kaken 2014-6p.pdf","filesize":[{"value":"196.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAKAMURA-H-kaken 2014-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44786/files/ME-PR-NAKAMURA-H-kaken 2014-6p.pdf"},"version_id":"c4c38347-b531-4744-8781-6b5130fd924c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"アレルギー疾患エピジェネティクスにおけるウイルス感染の役割解明とその予防法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アレルギー疾患エピジェネティクスにおけるウイルス感染の役割解明とその予防法の開発"},{"subitem_title":"Examination of the pathogenesis of epigenetics of virus infection for allergic diseases and development of preventive methods for it","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-21"},"publish_date":"2018-06-21","publish_status":"0","recid":"44786","relation_version_is_last":true,"title":["アレルギー疾患エピジェネティクスにおけるウイルス感染の役割解明とその予防法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:19:01.407879+00:00"}