{"created":"2023-07-27T06:51:23.046154+00:00","id":44787,"links":{},"metadata":{"_buckets":{"deposit":"a4bb071e-1c05-41cc-8cd2-20e59b70f4a3"},"_deposit":{"created_by":18,"id":"44787","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44787"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044787","sets":["2812:2813:2821"]},"author_link":["23691","44"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2010-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"リポソームカプセルのリン脂質2重層にNKT細胞活性化物質「α-GalCer」を挿入し、スギ花粉T細胞エピトープを封入し、CTLエピトープを表面に結合することによってリポソームワクチンを構築した。インフルエンザウイルス感染およびスギ花粉症モデルマウスを対象に、リポソームワクチンを6日間、予防的に投与し、IFV抗体価を指標として検討した結果、新しいインフルエンザウイルスワクチンの有効性が証明された。","subitem_description_type":"Abstract"},{"subitem_description":"We constructed liposomes vaccines, in α-GalCe, an activated substance in NKT cell was inserted into the bilayers of phospholipid liposome capsules, and T cell epitopes derived from Japanese cedar pollen was included and attached to the surface of CTL epitopes. We examined IFV titers in the model mouse infected by influenza virus and sensitized by Japanese cedar pollen. In results, the administration of the vaccines for 6 days before the infection showed the prophylactic effects.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22659121, 研究期間(年度):2010-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「インフルエンザウイルスとスギ花粉T細胞エピトープを用いた新しいリポソームワクチン」課題番号22659121\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22659121/22659121seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051126","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30231476"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30231476","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659121/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659121/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22659121/22659121seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22659121/22659121seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-21"}],"displaytype":"detail","filename":"ME-PR-NAKAMURA-H-kaken 2013-6p.pdf","filesize":[{"value":"387.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAKAMURA-H-kaken 2013-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44787/files/ME-PR-NAKAMURA-H-kaken 2013-6p.pdf"},"version_id":"a9ef207d-b156-4477-a081-a552dcf66ea3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"インフルエンザウイルスとスギ花粉T細胞エピトープを用いた新しいリポソームワクチン","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"インフルエンザウイルスとスギ花粉T細胞エピトープを用いた新しいリポソームワクチン"},{"subitem_title":"Newly development of liposomes vaccines using influenza virus and T cell epitope peptide derived from Japanese cedar pollen","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-21"},"publish_date":"2018-06-21","publish_status":"0","recid":"44787","relation_version_is_last":true,"title":["インフルエンザウイルスとスギ花粉T細胞エピトープを用いた新しいリポソームワクチン"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:37:27.148854+00:00"}