{"created":"2023-07-27T06:51:23.133479+00:00","id":44789,"links":{},"metadata":{"_buckets":{"deposit":"0ed9d448-4d3e-425d-a16b-62efc0597f6c"},"_deposit":{"created_by":18,"id":"44789","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44789"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044789","sets":["2812:2813:2826"]},"author_link":["23691","44"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-04","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"12p.","bibliographicVolumeNumber":"2005-2007","bibliographic_titles":[{"bibliographic_title":"平成19(2007)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2007 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アレルギー性疾患における環境と遺伝の相互作用の解明によってオーダーメード予防法を新たに提示するために、気管支喘息症とスギ花粉症患者における好酸球関連蛋白であるCC chemokine receptor(CCR)familyとEotaxin/CCL11,Eotaxin-2/CCL24,Eotaxin-3/CCL26、Monocyte chemoattractant protein-1(MCP-1,CCL2)の遺伝子多型を健常者と比較した。喘息症および花粉症におけるCCR3遺伝子の51C、CCL26の2497G、2563C、MCP-1遺伝子の2518Gの頻度が健常群に対して有意に多かった。また、これらの蛋白と重症度においても相関が認められた。したがってアレルギー発症および重症化におけるこれらの好酸球関連蛋白の臨床的な意義も証明された。また環境化学物質除去を目的として非晶鉄および活性炭を含む除去フィルターを新たに開発し、このフィルターでディーゼル排気粒子(Diesel exhaust particulate,DEP)を含む水をろ過し、アレルギーモデルマウスに投与し、気管支喘息の予防効果および軽減効果を検証した。そのフィルターによるDEP中に含まれるアレルギー促進物質の除去を試み、マウスへ投与を行ったところ、肺への好酸球および好中球の浸潤が有意に抑制され、ダニ抗原特異的IgG1抗体価も有意に下がった。病理標本上からも肺の炎症が抑制されていることがわかった。以上より新たに開発したフィルターが環境化学物質の除去によってアレルギーの発症を予防できることを示すことができた。","subitem_description_type":"Abstract"},{"subitem_description":"To propose tailor-made preventive methods for allergic diseases by clarification between environment and genes, we compared single nucleotide polymorphisms (SNP) of genes of eosinophil-related protein, e.g., CC chemokine receptor (CCR) family, Eotaxin/CCL11, Eotaxin-2/CCL24, Eotaxin-3/CCL26, Monocyte chemoattractant protein -1 (MCP-1, CCL2) between patients with asthma or Japanese cedar pollinosis and controls. We recognized significantly higher frequencies of 51 C in CCR3 gene, 2497G and 2563C in CCL26 gene, and 2518G in MCP-1 gene in patients with asthma or Japanese cedar pollinosis as compared to controls. There were significant correlations between serum levels of those proteins and severity of those allergic diseases. These results suggest the clinical significance of those eosinophils-related proteins in allergic diseases. Next, we developed the novel preventive methods for allergy, using the filter system incorporating activated carbon and amorphous iron(hydr)oxide, which efficiently removes diesel exhaust particulate (DEP). We demonstrated that removal of DEP by the filter system produced significant inhibition of allergic responses, e. g, eosinophils and neutrophils infiltration into lung tissues, lung inflammation and elevated Der f specific IgGl antibody level in asthma model mice BALB/c, which were sensitized and stimulated with Der f. Therefore, this filter system might be the most effective to prevent allergy development, if its use were started in our life as early as possible (e.g. in our infancy).","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17390174, 研究期間(年度):2005-2007","subitem_description_type":"Other"},{"subitem_description":"出典：「環境中物質と好酸球関連蛋白遺伝子の相互作用解明によるアレルギー疾患の予防」研究成果報告書　課題番号17390174\n  (KAKEN：科学研究費助成事業データベース（国立情報学研究所）)\n　　　本文データは著者版報告書より作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051128","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30231476"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30231476","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390174/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390174/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17390174/173901742007kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17390174/173901742007kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-21"}],"displaytype":"detail","filename":"ME-PR-NAKAMURA-H-kaken 2008-12p.pdf","filesize":[{"value":"615.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAKAMURA-H-kaken 2008-12p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44789/files/ME-PR-NAKAMURA-H-kaken 2008-12p.pdf"},"version_id":"12bafee6-3ff2-4e5b-97eb-fcc369c59f59"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"環境中物質と好酸球関連蛋白遺伝子の相互作用解明によるアレルギー疾患の予防","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"環境中物質と好酸球関連蛋白遺伝子の相互作用解明によるアレルギー疾患の予防"},{"subitem_title":"Prevention for allergic diseases by clarification of interaction between environmental chemicals and genes of eosinophil-related protein","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2826"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-21"},"publish_date":"2018-06-21","publish_status":"0","recid":"44789","relation_version_is_last":true,"title":["環境中物質と好酸球関連蛋白遺伝子の相互作用解明によるアレルギー疾患の予防"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:24:09.777029+00:00"}