{"created":"2023-07-27T06:51:23.309321+00:00","id":44793,"links":{},"metadata":{"_buckets":{"deposit":"dd2ad97a-2ee2-46ae-b8b2-524dce197bc0"},"_deposit":{"created_by":18,"id":"44793","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44793"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044793","sets":["2812:2813:2835"]},"author_link":["23691","44"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"9p.","bibliographicVolumeNumber":"1997-1998","bibliographic_titles":[{"bibliographic_title":"平成10(1998)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"1998 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"低レベルマイクロ波の全身暴露によってもたらされる内分泌免疫系への影響を脳内神経伝達物質との関連において解明することを目的に、マイクロ波(周波数2,450MHz、強度2mW/cm^2、90分間)暴露による脾臓細胞中ナチュラルキラー細胞活性(NKCA)、血中の諸指標と下垂体と胎盤のβ一エンドルフィン(βEP)の変化を妊娠ラットあるいは処女ラットにおいて検討した。このレベルのマイクロ波は、処女ラット、妊娠ラットでそれぞれ、0.8と0.9°Cの温度上昇をもたらしたが、血中コルチコステロンへの有意な変化は引き起こさなかった。処女ラットでは認められなかったが、妊娠ラットのマイクロ波暴露群のNKCAは非暴露群に比べ有意に減少した。オピオイド受容体拮抗剤であるnaloxoneの前処置では、妊娠期におけるマイクロ波によって低下したNKCAと、上昇したPRL、低下した視床下部medianeminenceのCRHをreverseした。一方、CRH受容体拮抗剤であるα-helicalCRHのicv投与によっても同じく、マイクロ波暴露によって上昇した血中プロラクチン(PRL)と下垂体βEPと、減少したNKCAをreverseした。これらの結果から、妊娠中のマイクロ波暴露による免疫機能低下には、マイクロ波暴露に際して視床下部CRH神経系と、視床下部あるいは下垂体のオピオイド神経系が刺激され、その結果、下垂体PRLが活性化されるという中枢性機序が考えられた。その際のマイクロ波による生体影響は、マイク口波の温熱作用と非温熱作用の両作用によると考えられた。 ","subitem_description_type":"Abstract"},{"subitem_description":"To examine the involvement of neuroendocrine systems m immunosuppression produced by low level microwaves in pregnant rats, we assayed some blood indicators and beta -endorphin (beta EP), pituitary lobes and placenta as well as splenic NKCA in virgin and/or pregnant rats exposed to microwaves (2 mW/cm^2 incident power density at 2450 MHz for 90 mm). Although microwaves elevated colonic temperatures by 0.8 ﾟC for virgin and 0.9 ﾟC for pregnant rats, and blood prolactin (PRL), and beta EP in blood and anterior pituitary lobes (AP) significantly, it did not change blood corticosterone as an index of hypothalamic-pituitary adrenal axis. Intraperitoneal administration of opioid receptor antagonist naloxone prior to microwave exposure reversed reduced NKCA and CRH in the median eminence, and increased PRL in pregnant rats during microwaves. Intracerebroventricular administration of CR1-I receptor antagonist alpha -helical CRH reversed the reduced NKCA and the elevated blood PRL and pituitary beta EP.These results suggest that immunosuppression produced by microwaves during pregnancy is mediated by the central CRH-opioid system. The pituitary PRI seems likely to be involved in the immunosuppression. These alterations during pregnancy may be due to both thermal and non-thermal actions of microwaves.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:09670382, 研究期間(年度):1997-1998","subitem_description_type":"Other"},{"subitem_description":"出典：「マイクロ波の低レベル変調波による妊娠母胎の神経内分泌免疫系への影響」研究成果報告書　課題番号09670382\n  (KAKEN：科学研究費助成事業データベース（国立情報学研究所）)\n　　　本文データは著者版報告書より作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051132","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30231476"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30231476","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670382/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670382/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-09670382/096703821998kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-09670382/096703821998kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-21"}],"displaytype":"detail","filename":"ME-PR-NAKAMURA-H-kaken 1999-9p.pdf","filesize":[{"value":"774.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAKAMURA-H-kaken 1999-9p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44793/files/ME-PR-NAKAMURA-H-kaken 1999-9p.pdf"},"version_id":"c7629a0d-a386-46fc-8692-b8365589732f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"マイクロ波の低レベル変調波による妊娠母胎の神経内分泌免疫系への影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マイクロ波の低レベル変調波による妊娠母胎の神経内分泌免疫系への影響"},{"subitem_title":"Effects of microwaves with low level and changing frequency on neuroendoctrine immune system in pregnant bodies","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2835"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-21"},"publish_date":"2018-06-21","publish_status":"0","recid":"44793","relation_version_is_last":true,"title":["マイクロ波の低レベル変調波による妊娠母胎の神経内分泌免疫系への影響"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:49:14.389192+00:00"}