{"created":"2023-07-27T06:51:24.273800+00:00","id":44817,"links":{},"metadata":{"_buckets":{"deposit":"92923d83-92d7-4160-a9d4-41f0481b98d3"},"_deposit":{"created_by":18,"id":"44817","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44817"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044817","sets":["2812:2813:2822"]},"author_link":["287","77302"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヘムオキシゲナーゼ-1(HO-1)が、単球あるいは血管内皮細胞における血液凝固・線溶系因子の産生を調節し抗血栓作用を有するかどうかについて検討した。その結果、HO-1代謝産物である一酸化炭素ならびにHO-1の発現を誘導するクルクミンをあらかじめ投与しておくと、炎症刺激による組織因子やプラスミノゲンアクチベーター・インヒビターの発現増加を抑制し、血栓傾向を阻止することを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"The purpose of the present study was to examine the antithrombotic role of heme oxygenase-1(HO-1) in detail, and to examine whether endothelial HO-1 induced by curcumin or carbon monoxide(CO) endogenously produced by HO-1 contributes to this antithrombotic effect. As a result, CO or endothelial HO-1 induced by curcumin would be effective for the prevention and treatment of hypercoagulable state by inflammation or oxidative stress.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21590613, 研究期間(年度):2009-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「生体侵襲時におけるヘムオキシゲナーゼ-1を介する血栓形成制御機構の解明」課題番号21590613\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590613/21590613seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051156","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域保健学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50251921"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50251921","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590613/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590613/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590613/21590613seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590613/21590613seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-22"}],"displaytype":"detail","filename":"ME-PR-MORISHITA-E-kaken 2012-6p.pdf","filesize":[{"value":"505.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MORISHITA-E-kaken 2012-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44817/files/ME-PR-MORISHITA-E-kaken 2012-6p.pdf"},"version_id":"e59d5c43-34a7-4939-8155-dfd526750bfa"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"生体侵襲時におけるヘムオキシゲナーゼ-1を介する血栓形成制御機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"生体侵襲時におけるヘムオキシゲナーゼ-1を介する血栓形成制御機構の解明"},{"subitem_title":"Investigation of antithrombotic effects of home oxygenase-1 on the hypercoagulable state by inflammation or oxidative stress","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"44817","relation_version_is_last":true,"title":["生体侵襲時におけるヘムオキシゲナーゼ-1を介する血栓形成制御機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:27:59.880296+00:00"}