{"created":"2023-07-27T06:51:25.550490+00:00","id":44846,"links":{},"metadata":{"_buckets":{"deposit":"2a7c6a94-95b7-4cd4-a61d-0c8579e5b0d0"},"_deposit":{"created_by":18,"id":"44846","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44846"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044846","sets":["2812:2813:2816"]},"author_link":["210"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脳アミロイドアンギオパチー（CAA）特異的なアミロイドβ蛋白（Aβ）株が存在し、それによってCAAが伝播するという仮説を検証する目的で、CAAを含むヒト剖検脳（n = 12）をR1.40 APP transgenicマウスに接種した。マウス脳ホモジネートのウェスタンブロット解析では、9例の剖検脳でAβを検出し、うち3例ではAβ40優位、6例ではAβ42優位であった。マウス脳のAβ免疫染色で、全てのマウス脳でAβ沈着を認め、Aβ42陽性面積率/Aβ40陽性面積率は多様であり、CAAの程度とAβ40陽性面積率と正の相関を認めた。ヒト脳Aβ沈着所見とマウス脳所見との関連を検討中である。","subitem_description_type":"Abstract"},{"subitem_description":"To examine a hypothesis that sporadic cerebral amyloid angiopathy (CAA) can be transmitted from humans to humans through CAA-specific amyloid β-protein (Aβ) strain, we performed transmission experiments to R1.40 APP transgenic mice with brain samples from patients with CAA without Alzheimer's disease (AD) (n = 3), AD with CAA (n = 3), AD without CAA (n = 3), and no AD/CAA (n = 3). Western blot of brains from the mice inoculated with the human brain samples presented with Aβ(n = 9)with Aβ40 (n = 3) or Aβ42 predominance (n = 6). Immunohistochemically, all the mice showed Aβ deposition in the brain with remarkable variations of Aβ42/Aβ40 ratios [Aβ42 immunoreactive areas (%)/Aβ40 immunoreactive areas (%)]. Severity of CAA correlated with Aβ40 immunoreactive areas (%). Study on correlations in the pattern of Aβ deposition between human and mouse brains is ongoing.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K15336, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「孤発性脳アミロイドアンギオパチーの伝播に関する研究」課題番号15K15336\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15336/15K15336seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051185","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80191336"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80191336","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15336/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15336/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15336/15K15336seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15336/15K15336seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-15"}],"displaytype":"detail","filename":"ME-PR-YAMADA-M-kaken 2018-4p.pdf","filesize":[{"value":"336.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-YAMADA-M-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44846/files/ME-PR-YAMADA-M-kaken 2018-4p.pdf"},"version_id":"1dd425ff-8802-41d3-b5aa-b7cb5f8c72a6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"孤発性脳アミロイドアンギオパチーの伝播に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"孤発性脳アミロイドアンギオパチーの伝播に関する研究"},{"subitem_title":"Study on transmission of sporadic cerebral amyloid angiopathey","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-15"},"publish_date":"2019-04-15","publish_status":"0","recid":"44846","relation_version_is_last":true,"title":["孤発性脳アミロイドアンギオパチーの伝播に関する研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:00:59.283535+00:00"}