{"created":"2023-07-27T06:51:25.594421+00:00","id":44847,"links":{},"metadata":{"_buckets":{"deposit":"e0b8eb61-5b6a-4868-8b17-b462607d14d3"},"_deposit":{"created_by":18,"id":"44847","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44847"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044847","sets":["2812:2813:2821"]},"author_link":["77348","210"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2010-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アミロイドβ蛋白(Aβ)あるいはそれ以外のアミロイド蛋白凝集体を投与することによってAβ凝集が促進されるかを検討した。Aβばかりでなく、αシヌクレイン蛋白、フィブロイン、セリシン、アクチン、カゼイン等の線維断片は試験管内でAβ40及びAβ42凝集を促進した(cross-seeding効果)。これらの蛋白凝集体はアルツハイマー病発症を促進する可能性があり、モデル動物への投与実験が進行中である。","subitem_description_type":"Abstract"},{"subitem_description":"Alzheimer’s disease (AD) may be transmissible by seeding or cross-seeding effects of exogenous protein aggregates through medical procedures, food, and so on. The purpose of this study is to determine whether Aβ or non-Aβ aggregates promote Aβ aggregation in in vitro and in vivo AD models. We found that fibrillar fragments of α-synuclein, fibroin, sericin, actin, casein, as well as Aβ40 and Aβ42 promoted aggregation of Aβ40 and Aβ42 in vitro. An in vivo study with AD model mice to which the aggregates of these proteins were administered is ongoing to reveal possible induction of AD by these protein aggregates.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22659170, 研究期間(年度):2010-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「医療行為や食品等によるアルツハイマー病の伝播あるいは発症促進に関する研究」課題番号22659170\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22659170/22659170seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051186","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80191336"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80191336","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659170/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659170/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22659170/22659170seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22659170/22659170seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-22"}],"displaytype":"detail","filename":"ME-PR-YAMADA-M-kaken 2013-4p.pdf","filesize":[{"value":"708.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-YAMADA-M-kaken 2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44847/files/ME-PR-YAMADA-M-kaken 2013-4p.pdf"},"version_id":"7f2c8267-d0ce-4601-95fb-2e03680ae2d4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"医療行為や食品等によるアルツハイマー病の伝播あるいは発症促進に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"医療行為や食品等によるアルツハイマー病の伝播あるいは発症促進に関する研究"},{"subitem_title":"Study on possible transmission of Alzheimer's disease with medical procedures and food","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"44847","relation_version_is_last":true,"title":["医療行為や食品等によるアルツハイマー病の伝播あるいは発症促進に関する研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:37:22.602377+00:00"}