{"created":"2023-07-27T06:51:25.638314+00:00","id":44848,"links":{},"metadata":{"_buckets":{"deposit":"e0923785-6ab6-4b7a-a107-08fb24f04064"},"_deposit":{"created_by":18,"id":"44848","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44848"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044848","sets":["2812:2813:2822"]},"author_link":["77348","210"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2008-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脳アミロイドアンギオパチー(CAA)関連脳出血リスク評価法およびCAA及びCAA関連脳出血の予防法の開発を行った。CAA例を調査研究し、CAA及びCAA関連血管障害のバイオマーカー、危険因子からなるリスク評価法を提案した。CAAのin vitroモデルを構築し、フェノール化合物のAβ線維化・オリゴマー化抑制効果、作用機序を解明した。それらはin vivoモデルにおいてCAAを含む脳アミロイド沈着を抑制した。","subitem_description_type":"Abstract"},{"subitem_description":"We investigated cerebral amyloid angiopathy(CAA) and CAA-related hemorrhages to develop methods of risk assessment and prevention. We propose a table of biomarkers and risk factors to predict future development of CAA-related hemorrhages and other disorders. We established an in vitro model of CAA. We revealed that natural phenolic compounds inhibited fibril formation and oligomerization of amyloidβ-protein(Aβ) in in vitro and in vivo models.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20390242, 研究期間(年度):2008-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「脳アミロイドアンギオパチー関連脳出血のリスク評価法および予防法の開発」課題番号20390242\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20390242/20390242seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051187","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80191336"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80191336","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390242/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390242/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20390242/20390242seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20390242/20390242seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-22"}],"displaytype":"detail","filename":"ME-PR-YAMADA-M-kaken 2012-4p.pdf","filesize":[{"value":"200.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-YAMADA-M-kaken 2012-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44848/files/ME-PR-YAMADA-M-kaken 2012-4p.pdf"},"version_id":"92564783-180f-4bce-9a9d-c12d3d815ed0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脳アミロイドアンギオパチー関連脳出血のリスク評価法および予防法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳アミロイドアンギオパチー関連脳出血のリスク評価法および予防法の開発"},{"subitem_title":"Development of risk assessment and prevention of cerebral amyloid angiopathy-related cerebral hemorrhages","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"44848","relation_version_is_last":true,"title":["脳アミロイドアンギオパチー関連脳出血のリスク評価法および予防法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:27:55.539710+00:00"}