{"created":"2023-07-27T06:51:25.770220+00:00","id":44851,"links":{},"metadata":{"_buckets":{"deposit":"5a37b329-42d6-4b8d-9371-bb3563ff4ce9"},"_deposit":{"created_by":18,"id":"44851","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44851"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044851","sets":["2812:2813:2819"]},"author_link":["255","77351"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2011-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"HIV-1感染児における病態進行に関連するウイルス並びに宿主因子を明らかにすることを目的とした。ケニアの早期発症児［5歳以下で抗レトロウイルス療法（ART）を開始した児29名］と遅発症児［10歳までARTを必要としなかった児32名］の間で、HIV-1 gagとnef遺伝子の多様性に有意差は認められなかった。遅発症児では早期発症児に比べ、病態遅延に関与するHLA型を持つ割合が高く、NefおよびGag蛋白質の両方でより多くのHLA-B関連エピトープを有していた。これらの結果から、HIV感染児では、宿主因子であるHLAがウイルス因子に比し、病態進行により重要な役割を果たしていることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"In the present study, we aimed at elucidating the factors related to disease progression in HIV-1 infected children. For this purpose, we compared sequence variations in the HIV-1 gag and nef genes between the rapid and slow progressors, and further investigated the presence of reported protective or susceptible HLA types and the predicted MHC-1 binding capability of the Gag and Nef epitopes between the two groups. Our present findings showed that the slow and rapid progressors did not have distinct sequence variations in both Nef and Gag. Compared to the rapid progressors, the slow progressors had more protective HLA-A alleles and more HLA-B-related epitopes in both Nef and Gag. These results suggest that the HLA, a host factor, plays a more important role in disease progression than the viral factors, such as variations in HIV-1 Nef and Gag, among HIV-1-infected Kenyan children.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23406013, 研究期間(年度):2011-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ケニアのHIV-1感染小児の病態進行に関与する宿主及びウイルス側因子の解明」課題番号23406013\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23406013/23406013seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051190","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10264756"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10264756","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23406013/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23406013/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23406013/23406013seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23406013/23406013seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-22"}],"displaytype":"detail","filename":"ME-PR-ICHIMURA-H-kaken 2015-6p.pdf","filesize":[{"value":"373.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-ICHIMURA-H-kaken 2015-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44851/files/ME-PR-ICHIMURA-H-kaken 2015-6p.pdf"},"version_id":"9691c16e-7b3b-4d0e-ac74-6247e5bf0af8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ケニアのHIV-1感染小児の病態進行に関与する宿主及びウイルス側因子の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ケニアのHIV-1感染小児の病態進行に関与する宿主及びウイルス側因子の解明"},{"subitem_title":"Comparison of the virologic and host characteristics between HIV-1-infected Kenyan children with rapid and slow disease progression","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"44851","relation_version_is_last":true,"title":["ケニアのHIV-1感染小児の病態進行に関与する宿主及びウイルス側因子の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:43:20.186677+00:00"}