{"created":"2023-07-27T06:51:25.814489+00:00","id":44852,"links":{},"metadata":{"_buckets":{"deposit":"4cdf8911-9442-4ad2-aced-6df67e75cce8"},"_deposit":{"created_by":18,"id":"44852","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44852"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044852","sets":["2812:2813:2828"]},"author_link":["255","77351"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"9p.","bibliographicVolumeNumber":"2002-2005","bibliographic_titles":[{"bibliographic_title":"平成17(2005)年度 科学研究費補助金 基盤研究(A) 研究成果報告書"},{"bibliographic_title":"2005 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"(A).ケニアにおけるHIV母子感染と感染児の病態進行速度に影響を及ぼす因子の検討:HIV母子感染例の大半を占めるアフリカにおいて、宿主因子がHIV母子感染に与える影響を調査した報告は少なく、その評価は確立していない。ケニア西部の逆転写酵素阻害剤ジドブジン(ZDV)短期投与によるHIV母子感染予防のコホート研究において、(1)CCR5プロモーター領域内の-2132T/T及び-2554T/TがHIV母子感染の危険を増大し、RANTES-403A/Aが抑制的に働く可能性が示唆され、(2)病態進行速度に影響を与える有意な宿主因子は認められなかった。また、感染児のウイルスにはZDV耐性をひきおこすとされる既知のアミノ酸置換はみられなかったこと、ならびに短期ZDV投与前後の母親のウイルスクローンの一部にZDV耐性をひきおこすとされる既知のアミノ酸置換がいくつかみられたが、いずれも2次変異のみであったことより、短期ZDV投与にもかかわらず母子感染が起こった原因は、ZDV耐性ウイルスが誘導され児へ感染したことによるものではないことが示唆された。\n(B)日本のHIV感染血友病患者の病態進行速度に影響を及ぼす宿主因子の検討:これまでにわれわれのグループは、CCR5プロモーター領域のSNPが日本のHIV-1感染血友病患者の病態進行に影響を与えることを報告した。今回、さらにSDF-13A'、RANTES・IL-4・DC-SIGNプロモーター領域内のSNPsに着目し、HIV-1感染後AIDS発症までの期間との関係を明らかにすることを目的として検討を行った。その結果、日本のHIV-1感染血友病患者において、RANTES-28GはAIDS発症遅延に、そしてDC-SIGN-139CはAIDS発症促進に関連することが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"(1)Investigation of the factors influencing on mother-to-child transmission (MTCT) of HIV-1 and disease progression : There have been few reports on the factors influencing on HIV-1 MTCT in Africa, where most cases of HIV MTCT exist, and the effect of host immune factors on clinical course left unconfirmed. In the cohort study on the prevention of MTCT using short course zidovudine (ZDV) in western Kenya, we found that CCR5-2132T/T and -2554T/T were associated with increased HIV-1 MTCT and RANTES-403 A/A was associated with decreased MTCT among infants whose mother took ZDV, and that no SNP (single nucleotide polymorphism) analyzed in the study was found to be associated with mortality rate at the age of 24 months. In addition, no ZDV-resistant associated mutation was observed in infants' HIV-1 clones, and some ZDV-resistant associated mutations were observed in a part of HIV-1 clones sampled from the mothers before and after ZDV-treatment, but they were all secondary mutations. These results suggest that the cause of MTCT of HIV-1 in spite of short-term ZDV treatment was not associated with an induction of ZDV-resistant mutants.\n(2)Factors influencing on the clinical courses among HIV-infected Japanese hemophiliacs : We previously reported the relationship between SNPs in the CCR5 promoter region and the clinical courses in HIV-1-infected Japanese hemophiliacs. In the current study, we further analyzed the relationship between the SNPs, such as RANTES promoter-28G/-403A, RANTESIn1.1C, SDF-1 3'A, IL-4 promoter-589T and DC-SIGNpromoter-139C/-336C, and disease progression, and found that RANTES-28G was associated with delayed AIDS progression, while DCSIGN-139C was associated with accelerated AIDS progression in HIV-1-infected Japanese hemophiliacs.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:14256005, 研究期間(年度):2002-2005","subitem_description_type":"Other"},{"subitem_description":"出典：「HIV母子感染ならびにエイズ発症に影響を及ぼす因子の解明」研究成果報告書　課題番号14256005\n  (KAKEN：科学研究費助成事業データベース（国立情報学研究所）)\n　　　本文データは著者版報告書より作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051191","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10264756"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10264756","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14256005/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14256005/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-14256005/142560052005kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-14256005/142560052005kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-22"}],"displaytype":"detail","filename":"ME-PR-ICHIMURA-H-kaken 2007-9p.pdf","filesize":[{"value":"355.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-ICHIMURA-H-kaken 2007-9p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44852/files/ME-PR-ICHIMURA-H-kaken 2007-9p.pdf"},"version_id":"d6377a79-caca-46a6-a008-2ea0399d1e17"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"HIV母子感染ならびにエイズ発症に影響を及ぼす因子の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HIV母子感染ならびにエイズ発症に影響を及ぼす因子の解明"},{"subitem_title":"Investigation of the factors influencing on HIV mother-to-child transmission and disease progression","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2828"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"44852","relation_version_is_last":true,"title":["HIV母子感染ならびにエイズ発症に影響を及ぼす因子の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:31:28.616340+00:00"}