{"created":"2023-07-27T06:51:29.057078+00:00","id":44926,"links":{},"metadata":{"_buckets":{"deposit":"221cca86-078c-45de-a1c7-3eb21130014e"},"_deposit":{"created_by":18,"id":"44926","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44926"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044926","sets":["2812:2813:2816"]},"author_link":["622","45199"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-04-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"バレット上皮発生率はコントロール群；94％、プランルカスト群；69％、食道腺癌発生率はコントロール群；69％、プランルカスト群；15％、いずれもプランルカスト投与で有意に抑制された。組織増殖活性はプランルカスト投与で抑制され、アポトーシス増加した。浸潤マクロファージはプランルカスト群で減少していた。\nプランルカスト投与により、バレット上皮・食道腺癌の発生が抑制された。LOX阻害により消化液逆流に伴う慢性的な炎症状態を抑制することが、発癌抑制につながったと考えられる。炎症細胞の中でも特にマクロファージの浸潤が抑制されていた。マクロファージによる過剰な組織増殖刺激が発癌要因の一つと考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"The incidence of Barrett’s epithelium in control group was 94%, in pranlukast group; 69%, the incidence of esophageal adenocarcinoma in control group; 69%, pranlukast group; 15%. Both of Barrett’s epithelium and esophageal adenocarcinoma generation were significantly suppressed by pranlukast administration. Pranlukast administration suppressed tissue growth activity and increased apoptosis. Infiltrating macrophages were reduced by pranlukast administration.\nThe administration of pranlukast suppressed the generation of Barrett's epithelium and· esophageal adenocarcinoma. Suppression of chronic inflammatory condition by LOX inhibition lead to suppression of carcinogenesis. Moreover, infiltration of macrophages was particularly suppressed among inflammatory cells. Excessive stimulation of tissue growth by macrophages was considered to be one of carcinogenic factors.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K10090, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「慢性炎症を背景とした食道発癌におけるアラキドン酸カスケードの制御と発癌抑制効果」課題番号15K10090\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K10090/15K10090seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051265","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70460350"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70460350","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10090/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10090/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K10090/15K10090seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K10090/15K10090seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-18"}],"displaytype":"detail","filename":"HO-PR-OYAMA-K-kaken 2018-4p.pdf","filesize":[{"value":"206.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-OYAMA-K-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44926/files/HO-PR-OYAMA-K-kaken 2018-4p.pdf"},"version_id":"89a610e5-3e7e-4edc-9c56-c29ff88ff0e6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"慢性炎症を背景とした食道発癌におけるアラキドン酸カスケードの制御と発癌抑制効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"慢性炎症を背景とした食道発癌におけるアラキドン酸カスケードの制御と発癌抑制効果"},{"subitem_title":"The chemoprevention of esophageal carcinogenesis with chronic inflammation by the suppression of lipoxygenase","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-18"},"publish_date":"2019-04-18","publish_status":"0","recid":"44926","relation_version_is_last":true,"title":["慢性炎症を背景とした食道発癌におけるアラキドン酸カスケードの制御と発癌抑制効果"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:00:52.531648+00:00"}