{"created":"2023-07-27T06:51:29.146751+00:00","id":44928,"links":{},"metadata":{"_buckets":{"deposit":"71ac7b79-f38c-4893-9051-a7a65c9eb7f2"},"_deposit":{"created_by":18,"id":"44928","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44928"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044928","sets":["2812:2813:2815"]},"author_link":["2987","22572"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-17","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝移植後に生じる慢性拒絶やオキサリプラチンなどの抗癌剤による肝障害、造血幹細胞移植後の重篤な肝障害は類洞閉塞症候群 (SOS)と呼ばれる原因不明の病態であるが、これらは脾腫などの門脈圧亢進症状を呈しながら中心静脈域(zone 3)を中心として慢性に進行 するという共通の特徴を有している。今回の研究ではSOSの原因としてzone 3を中心としたDisse腔内での血管外血小板凝集が大きな役割を担うと仮説を立て、ラットSOSモデルを用いて肝の免疫組織学的検討および電子顕微鏡によりzone 3における血小板のDisse腔内での凝集を確認し、抗血小板薬によりSOS発症が抑制できることを示した。","subitem_description_type":"Abstract"},{"subitem_description":"Chronic rejection after liver transplantation, anticancer agents such as oxaliplatin, and hematopoietic stem cell transplantation are cause sinusoid obstruction syndrome (SOS) characterized by splenomegaly and thrombocytopenia, resulting in liver dysfunction. SOS have the common feature of progressing chronically around the central vein (zone 3). If it is hypothesized that extravascular platelet aggregation in the Disse’s space cause of SOS, it will be possible to unify the series of pathogenesis that accompanies SOS. In this study, we aimed to confirm the state of platelet aggregation with rat SOS model and to examine the preventive effect of antiplatelet drug on SOS. We made rat SOS model with monocrotaline and discovered the presence of platelet aggregation in the Disse’s space around central vein (zone 3) with immunohistological examination and electron microscopy, and also certified that antiplatelet drug (cilostazol) has preventive effect for SOS. ","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K10158, 研究期間(年度):2015-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「肝の難病“類洞閉塞症候群”の病態解明と新規予防法・治療法の開発」課題番号15K10158\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K10158/15K10158seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051267","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院肝胆膵・移植外科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00436825"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00436825","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10158/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10158/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K10158/15K10158seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K10158/15K10158seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-24"}],"displaytype":"detail","filename":"HO-PR-TAJIMA-H-kaken 2019-4p.pdf","filesize":[{"value":"206.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-TAJIMA-H-kaken 2019-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44928/files/HO-PR-TAJIMA-H-kaken 2019-4p.pdf"},"version_id":"0cc777d8-1e26-40b0-9c86-07abaa209249"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝の難病“類洞閉塞症候群”の病態解明と新規予防法・治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝の難病“類洞閉塞症候群”の病態解明と新規予防法・治療法の開発"},{"subitem_title":"Elucidation of pathophysiology of Sinusoidal Obstruction Syndrome and development of new prevention and treatment methods","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-24"},"publish_date":"2020-04-24","publish_status":"0","recid":"44928","relation_version_is_last":true,"title":["肝の難病“類洞閉塞症候群”の病態解明と新規予防法・治療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:35:41.763127+00:00"}