{"created":"2023-07-27T06:51:29.191804+00:00","id":44929,"links":{},"metadata":{"_buckets":{"deposit":"2c6d31f9-f6e0-4882-9cd4-4607250ce5fa"},"_deposit":{"created_by":18,"id":"44929","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44929"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044929","sets":["2812:2813:2820"]},"author_link":["2987","22572"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"癌の転移・浸潤や組織の線維化において上皮間葉転換(EMT: Epithelial mesenchymal transition)が注目されていが、抗癌治療そのものにより癌細胞にEMTが誘導されることが近年話題となっている。ヒストン脱アセチル酵素 (HDAC) 阻害薬やタキサン系抗癌剤の少量投与が細胞のEMTを抑制するとともに組織の線維化も抑制することが知られている。今回の研究においてタキサン系薬剤paclitaxelが原発性肝癌（肝内胆管癌）細胞株のEMTを抑制し、paclitaxelおよびHDAC 阻害薬 （バルプロ酸ナトリウム）が肝星細胞の活性化を抑制することを実験的に示し、報告した。","subitem_description_type":"Abstract"},{"subitem_description":"Epithelial-mesenchymal transition (EMT) in tissue fibrosis and cancer metastasis and invasion has been noted, but the EMT is induced in cancer cells by anti-cancer therapy itself has become a hot topic in recent years. It is well known that tissue fibrosis and EMT are inhibited by low dose administered taxan and histone deacetylase (HDAC) inhibitor. It has been shown that paclitaxel suppresses the induction of EMT in primary liver cancer (intrahepatic cholangiocarcinoma) cell line in the current study, HDAC inhibitors (sodium valproate) and paclitaxel inhibited activation of hepatic stellate cells.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23591981, 研究期間(年度):2011-2013","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「肝細胞癌における背景肝の線維化ならびに抗癌治療誘発EMT抑制に関する研究」課題番号23591981\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591981/23591981seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051268","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院肝胆膵・移植外科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00436825"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00436825","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591981/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591981/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591981/23591981seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591981/23591981seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-28"}],"displaytype":"detail","filename":"ME-PR-TAJIMA-H-kaken 2014-4p.pdf","filesize":[{"value":"90.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAJIMA-H-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44929/files/ME-PR-TAJIMA-H-kaken 2014-4p.pdf"},"version_id":"3a605cd1-7017-4a0f-9646-08e16e121c9a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝細胞癌における背景肝の線維化ならびに抗癌治療誘発EMT抑制に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝細胞癌における背景肝の線維化ならびに抗癌治療誘発EMT抑制に関する研究"},{"subitem_title":"Research on inhibition of anti-cancer treatment-induced EMT and fibrosis in the back ground liver and hepatocellular carcinoma","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-28"},"publish_date":"2018-06-28","publish_status":"0","recid":"44929","relation_version_is_last":true,"title":["肝細胞癌における背景肝の線維化ならびに抗癌治療誘発EMT抑制に関する研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:18:55.670121+00:00"}