{"created":"2023-07-27T06:51:29.281222+00:00","id":44931,"links":{},"metadata":{"_buckets":{"deposit":"b2c8f777-105a-44df-bc4f-142258bbab23"},"_deposit":{"created_by":18,"id":"44931","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44931"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044931","sets":["2812:2813:2820"]},"author_link":["77692","569"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"胚性幹細胞(ES細胞)特異的転写因子のZfp57は，ヒトがん細胞において，imprinting 遺伝子である IGF2 の loss of imprinting を介して AKT をリン酸化し，造腫瘍性を亢進させるとともに，血行性転移能獲得に中心的な役割を果たすことを明らかにした．Zfp57 は「がん遺伝子」として機能する．","subitem_description_type":"Abstract"},{"subitem_description":"Zfp57 is required for the tumorigenicity and hematogenous metastaic ability of humoral cancer cell line by upregulating IGF2 expression and Zfp57 activates AKT through IGF2 signaling.\nZfp57 is over-expressed in several humoral cancer tissues and especially in liver metastasis of colorectal cancer.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23591982, 研究期間(年度):2011-2013","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「胚性幹細胞研究に基づく肝癌幹細胞増殖機構の解明」課題番号23591982\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591982/23591982seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051270","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院肝胆膵・移植外科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40377396"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40377396","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591982/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591982/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591982/23591982seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591982/23591982seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-28"}],"displaytype":"detail","filename":"ME-PR-TAKAMURA-H-kaken 2014-5p.pdf","filesize":[{"value":"3.5 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAKAMURA-H-kaken 2014-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44931/files/ME-PR-TAKAMURA-H-kaken 2014-5p.pdf"},"version_id":"a64505a6-4cc1-427b-a1b6-44f049737d86"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胚性幹細胞研究に基づく肝癌幹細胞増殖機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胚性幹細胞研究に基づく肝癌幹細胞増殖機構の解明"},{"subitem_title":"Elucidation of the proliferative mechanism of liver cancer stem cell based on the study of embryonal stem cell","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-28"},"publish_date":"2018-06-28","publish_status":"0","recid":"44931","relation_version_is_last":true,"title":["胚性幹細胞研究に基づく肝癌幹細胞増殖機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:18:54.147246+00:00"}