{"created":"2023-07-27T06:51:29.325616+00:00","id":44932,"links":{},"metadata":{"_buckets":{"deposit":"b6d8b4a0-4f89-46b6-9792-58dbfe5697bb"},"_deposit":{"created_by":18,"id":"44932","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44932"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044932","sets":["2812:2813:2823"]},"author_link":["77692","569"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-16","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ラジオ波焼灼療法(RFA)や肝動脈塞栓療法(TACE)による肝細胞癌(HCC)治療後の肝内局所再発でしばしば見られる治療抵抗性への形質転換(高度な浸潤・転移・増殖能の獲得)であるEpithelial Mesenchymal Transition (EMT)を,臨床検体を用いて明らかにした.さらにin vivo実験系を用いてHCCのEMT化にHIF-1αがきわめて重要な働きをしていることを明らかにし,その阻害剤を用いることでEMT化が抑制されることを証明した.","subitem_description_type":"Abstract"},{"subitem_description":"I clarified epithelial mesenchymal transition (EMT) which was transformation to treatment resistance to be often seen in local recurrence in the post-treatment (RFA and TACE) liver of the hepatocellular carcinoma (HCC). Furthermore I elucidated the molecular mechanism about EMT of HCC and clarified molecular target to prevent EMT with in vivo experimental model. It was probed that HIF-1 α has had extremely important role in EMT of the HCC and the EMT was restrained by using a repressor of HIF-1α such as valproic acid (VPA).","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「肝細胞癌のMesenchymal Transition機序の解明」課題番号20591603\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591603/20591603seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院肝胆膵・移植外科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051271","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40377396"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40377396","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591603/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591603/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591603/20591603seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591603/20591603seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-28"}],"displaytype":"detail","filename":"ME-PR-TAKAMURA-H-kaken 2011-4p.pdf","filesize":[{"value":"572.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAKAMURA-H-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44932/files/ME-PR-TAKAMURA-H-kaken 2011-4p.pdf"},"version_id":"96bf82bc-f972-464b-b9d0-e5a3987c20e8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝細胞癌のMesenchymal Transition機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝細胞癌のMesenchymal Transition機序の解明"},{"subitem_title":"Elucidation of mechanism of mesenchymal transition in HCC","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-28"},"publish_date":"2018-06-28","publish_status":"0","recid":"44932","relation_version_is_last":true,"title":["肝細胞癌のMesenchymal Transition機序の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:17:13.739752+00:00"}