{"created":"2023-07-27T06:51:29.639678+00:00","id":44939,"links":{},"metadata":{"_buckets":{"deposit":"0d4c44ea-8fb6-4c7a-9a29-3f6ca1c62241"},"_deposit":{"created_by":18,"id":"44939","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44939"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044939","sets":["2812:2813:2817"]},"author_link":["77703","77702"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"中枢神経悪性リンパ腫 (び漫性大細胞型B細胞リンパ腫)の早期診断と有効な治療薬の確立を目指し、本研究ではサイトカインIL-10に注目した。中枢神経悪性リンパ腫患者の脳脊髄液におけるIL-10を測定し有意な上昇を検出した。手術で得られた病理標本切片を用いて免疫組織学的にIL-10、IL-10Rの発現の有無を検討し、他腫瘍や正常脳組織とその発現を比較した。IL-10,IL-10Rの陽性コントロールとしては脾臓の組織標本を用いた。リンパ腫細胞の細胞質にIL-10および細胞膜にレセプターIL-10の過剰発現を認めた。","subitem_description_type":"Abstract"},{"subitem_description":"Preoperative diagnosis of central nervous system (CNS) lymphoma is very important in neurosurgery because biopsy can be selected for pathological diagnosis.The purpose of this study was to evaluate the diagnostic value of IL-10 in cerebrospinal fluid (CSF) in patients with CNS lymphoma compared with other CNS diseases, including CNS tumors and inflammatory diseases. CSF IL-10 were measured in patients with CNS lymphoma and 26 non-lymphoma patients. CSF IL-10 was detected at significant levels. These results indicate that CSF IL-10 is a superior biomarker for initial screening for patients with CNS lymphoma and give useful information for planning of a neurosurgical procedure.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K19981, 研究期間(年度):2015-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「IL-10産生による中枢神経系悪性リンパ腫の免疫回避と増殖/浸潤機構の解明」研究成果報告書　課題番号15K19981\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K19981/15K19981seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院脳神経外科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051278","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70387372"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70387372","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K19981/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K19981/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K19981/15K19981seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K19981/15K19981seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-28"}],"displaytype":"detail","filename":"ME-PR-SASAGAWA-Y-kaken 2017-4p.pdf","filesize":[{"value":"140.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SASAGAWA-Y-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44939/files/ME-PR-SASAGAWA-Y-kaken 2017-4p.pdf"},"version_id":"d761a6c1-efd1-4ba6-877b-2ed3a9da9be3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"IL-10産生による中枢神経系悪性リンパ腫の免疫回避と増殖/浸潤機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"IL-10産生による中枢神経系悪性リンパ腫の免疫回避と増殖/浸潤機構の解明"},{"subitem_title":"Central nervous malignant lymphoma with IL-10 secretion","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-28"},"publish_date":"2018-06-28","publish_status":"0","recid":"44939","relation_version_is_last":true,"title":["IL-10産生による中枢神経系悪性リンパ腫の免疫回避と増殖/浸潤機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:31:36.637964+00:00"}